BCL2L14 抗体 (C-Term)
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Quick Overview for BCL2L14 抗体 (C-Term) (ABIN783818)
抗原
See all BCL2L14 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects Bcl-2-like 14 at C-term.
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交叉反应 (详细)
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Ion exchange chromatography purified
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免疫原
- 15 amino acids near the C-terminus of human Bcl-G
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- BCL2L14 (BCL2-Like 14 (Apoptosis Facilitator) (BCL2L14))
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别名
- Bcl-2-Like 14
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背景
- Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain (reviewed in 1 and 2). BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bcl-G (3). The mRNA of Bcl-G encodes 2 isoforms, Bcl-GL, which is widely expressed in multiple tissues, and Bcl-GS, which is only found in testis. The Bcl-GS protein is predominantly localized to cytoplasmic organelles whereas Bcl-GL was distributed throughout the cytosol. Overexpression of either protein induced apoptosis, although Bcl-GS was far more potent than Bcl-GS. Apoptosis induction was dependent on the BH3 domain and could be suppressed by co-expression with the anti-apoptotic Bcl-XL protein (3).Synonyms: Apoptosis facilitator Bcl-2-like protein 14, BCL2L14, BCLG, Bcl-G, Bcl2-L-14
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基因ID
- 79370
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NCBI登录号
- NP_110393
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UniProt
- Q9BZR8
抗原
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