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CXXC4 抗体 (N-Term)

This anti-CXXC4 antibody is a Rabbit Polyclonal antibody detecting CXXC4 in WB, EIA. Suitable for Human, Mouse, Rat.
产品编号 ABIN783773
发货至: 中国

Quick Overview for CXXC4 抗体 (N-Term) (ABIN783773)

抗原

See all CXXC4 抗体
CXXC4 (CXXC Finger Protein 4 (CXXC4))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

  • 19
多克隆

标记

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This CXXC4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Enzyme Immunoassay (EIA)
  • 抗原表位

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    N-Term

    特异性

    This antibody detects CXXC4 at N-term.

    交叉反应 (详细)

    Species reactivity (tested):Human, mouse, rat

    纯化方法

    Affinity chromatography purified via peptide column

    免疫原

    18 amino acid peptide near the amino terminus of human CXXC4
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • 抗原

    CXXC4 (CXXC Finger Protein 4 (CXXC4))

    别名

    CXXC4

    背景

    CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.Synonyms: CXXC-type zinc finger protein 4, IDAX, Inhibition of the Dvl and axin complex protein

    基因ID

    80319

    NCBI登录号

    NP_079488

    UniProt

    Q9H2H0
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