CXXC4 抗体 (N-Term)
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Quick Overview for CXXC4 抗体 (N-Term) (ABIN783773)
抗原
See all CXXC4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects CXXC4 at N-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 18 amino acid peptide near the amino terminus of human CXXC4
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anti-CXXC Finger Protein 4 (CXXC4) (AA 1-198) antibody
CXXC4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CXXC Finger Protein 4 (CXXC4) (AA 158-185), (C-Term) antibodyCXXC4 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22171 unconjugated
anti-CXXC Finger Protein 4 (CXXC4) (AA 164-194), (C-Term) antibodyCXXC4 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-CXXC Finger Protein 4 (CXXC4) (N-Term) antibodyCXXC4 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- CXXC4 (CXXC Finger Protein 4 (CXXC4))
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别名
- CXXC4
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背景
- CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.Synonyms: CXXC-type zinc finger protein 4, IDAX, Inhibition of the Dvl and axin complex protein
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基因ID
- 80319
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NCBI登录号
- NP_079488
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UniProt
- Q9H2H0
抗原
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