KPNA6 抗体 (N-Term)
Quick Overview for KPNA6 抗体 (N-Term) (ABIN783737)
抗原
See all KPNA6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects KPNA6 / Importin alpha-7 at N-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 13 amino acid peptide near the amino terminus of human KPNA6
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anti-Karyopherin alpha 6 (Importin alpha 7) (KPNA6) (AA 277-536) antibody
KPNA6 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 6 (Importin alpha 7) (KPNA6) (Internal Region) antibodyVerified KPNA6 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Karyopherin alpha 6 (Importin alpha 7) (KPNA6) (AA 101-200) antibodyKPNA6 适用: 人, 小鼠 WB, ELISA, IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 6 (Importin alpha 7) (KPNA6) (AA 74-123) antibodyKPNA6 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 兔, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
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别名
- KPNA6 / Importin alpha-7
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背景
- Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.Synonyms: IPOA7, KPNA6, Karyopherin subunit alpha-6
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基因ID
- 23633
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NCBI登录号
- NP_036448
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UniProt
- O60684
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途径
- Protein targeting to Nucleus
抗原
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