NLRP4 抗体 (Center)
This 兔 多克隆 anti-NLRP4 antibody specifically detects NLRP4 in WB 和 EIA. The antibody is reactive with 人 和 小鼠 samples.
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产品编号 ABIN783705
发货至:
中国
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Quick Overview for NLRP4 抗体 (Center) (ABIN783705)
抗原
See all NLRP4 抗体
NLRP4
(NLR Family, Pyrin Domain Containing 4 (NLRP4))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This NLRP4 antibody is un-conjugated
应用范围
Western Blotting (WB), Enzyme Immunoassay (EIA)
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抗原表位
- Center
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特异性
- This antibody detects NALP4 at Center.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 13 amino acid peptide near the center of human NALP4
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anti-NLR Family, Pyrin Domain Containing 4 (NLRP4) (AA 351-450) antibody
NLRP4 适用: 人, 大鼠 ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 4 (NLRP4) (AA 121-149) antibodyNLRP4 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))
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别名
- NALP4
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背景
- NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kB induction by TNF-a and IL-1b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-a and IKK-b, suggesting that NALP4 is critical in modulating NF-kB activity.Synonyms: LRR and PYD domains-containing protein 4, NACHT, NLRP4, PAN2, PYPAF4, RNH2
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基因ID
- 147945
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NCBI登录号
- NP_604393
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UniProt
- Q96MN2
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途径
- Inflammasome
抗原
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