FRMPD2 抗体 (N-Term)
This anti-FRMPD2 antibody is a 兔 多克隆 antibody detecting FRMPD2 in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠.
Quick Overview for FRMPD2 抗体 (N-Term) (ABIN783582)
抗原
See all FRMPD2 抗体
FRMPD2
(FERM and PDZ Domain Containing 2 (FRMPD2))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This FRMPD2 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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抗原表位
- N-Term
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 15 amino acid peptide from near the amino terminus of human FRMPD2
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anti-FERM and PDZ Domain Containing 2 (FRMPD2) (AA 1-261) antibody
FRMPD2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-FERM and PDZ Domain Containing 2 (FRMPD2) (N-Term) antibodyFRMPD2 适用: 人, Cow, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody (in aliquots) at -20 °C.
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- FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))
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别名
- FRMPD2
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背景
- The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL (4). FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.Synonyms: FERM and PDZ domain-containing protein 2, PDZ domain-containing protein 4, PDZ domain-containing protein 5C, PDZD5C, PDZK4, PDZK5C
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基因ID
- 143162
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NCBI登录号
- NP_001018081
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UniProt
- Q68DX3
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途径
- Cell-Cell Junction Organization
抗原
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