OTUD5 抗体 (C-Term)
Quick Overview for OTUD5 抗体 (C-Term) (ABIN783570)
抗原
See all OTUD5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects OTUD5 at C-term.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 13 amino acid peptide near the carboxy terminus of the human OTUD5
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anti-OTU Domain Containing 5 (OTUD5) (AA 51-183) antibody
OTUD5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 5 (OTUD5) (AA 550-600) antibodyOTUD5 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-OTU Domain Containing 5 (OTUD5) (AA 501-571) antibodyOTUD5 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- OTUD5 (OTU Domain Containing 5 (OTUD5))
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别名
- OTUD5
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背景
- OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein. Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses. It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus. Multiple isoforms of OTUD5 are known to exist.Synonyms: DUBA, Deubiquitinating enzyme A, OTU domain-containing protein 5
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基因ID
- 55593
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NCBI登录号
- NP_001129629
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UniProt
- Q96G74
抗原
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