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FOXO4 抗体 (N-Term)

This anti-FOXO4 antibody is a 兔 多克隆 antibody detecting FOXO4 in WB 和 EIA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN783542
发货至: 中国

Quick Overview for FOXO4 抗体 (N-Term) (ABIN783542)

抗原

See all FOXO4 抗体
FOXO4 (Forkhead Box O4 (FOXO4))

适用

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人, 小鼠, 大鼠

宿主

  • 134
  • 1
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克隆类型

  • 122
  • 14
多克隆

标记

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This FOXO4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Enzyme Immunoassay (EIA)
  • 抗原表位

    • 26
    • 18
    • 14
    • 9
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    • 1
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    N-Term

    交叉反应 (详细)

    Species reactivity (tested):Human, mouse, rat

    纯化方法

    Affinity chromatography purified via peptide column

    免疫原

    16 amino acid peptide near the amino terminus of human FOXO4
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS containing 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the antibody (in aliquots) at -20 °C.
  • 抗原

    FOXO4 (Forkhead Box O4 (FOXO4))

    别名

    FOXO4 / AFX1 / MLLT7

    背景

    FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity.Synonyms: Fork head domain transcription factor AFX1, Forkhead box protein O4

    基因ID

    4303

    NCBI登录号

    NP_001164402

    UniProt

    P98177

    途径

    Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
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