TYW1 抗体 (C-Term)
This anti-TYW1 antibody is a 兔 多克隆 antibody detecting TYW1 in WB 和 EIA. Suitable for 人 和 大鼠.
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Quick Overview for TYW1 抗体 (C-Term) (ABIN783488)
抗原
See all TYW1 抗体
TYW1
(tRNA-YW Synthesizing Protein 1 Homolog (TYW1))
适用
人, 大鼠
宿主
兔
克隆类型
多克隆
标记
This TYW1 antibody is un-conjugated
应用范围
Western Blotting (WB), Enzyme Immunoassay (EIA)
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抗原表位
- C-Term
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特异性
- This antibody detects TYW1 / RSAFD1 at C-term. TYW1 antibody is predicted to not cross-react with other TYW protein family members. At least three isoforms of TYW1 are known to exist, this antibody will only detect the two larger isoforms.
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交叉反应 （详细）
- Species reactivity (tested):Human, rat
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 19 amino acid peptide near the carboxy terminus of human TYW1
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anti-tRNA-YW Synthesizing Protein 1 Homolog (TYW1) (AA 1-384) antibody
TYW1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G5 unconjugated
anti-tRNA-YW Synthesizing Protein 1 Homolog (TYW1) (AA 1-384) antibodyTYW1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- TYW1 (tRNA-YW Synthesizing Protein 1 Homolog (TYW1))
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别名
- TYW1 / RSAFD1
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背景
- TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7. Defects in some of the genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome, suggesting that TYW1 may play a role in these conditions.Synonyms: Radical S-adenosyl methionine and flavodoxin domain-containing protein 1, tRNA wybutosine-synthesizing protein 1 homolog, tRNA-yW-synthesizing protein
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基因ID
- 55253
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NCBI登录号
- NP_060734
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UniProt
- Q9NV66
抗原
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