BCL9L 抗体 (N-Term)
Quick Overview for BCL9L 抗体 (N-Term) (ABIN783409)
抗原
See all BCL9L 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- This antibody detects Bcl-9-like protein at N-term. It is predicted to not cross-react with other Bcl family members. At least four isoforms of Bcl9L are known to exist, this antibody will detect all four.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 20 amino acid peptide near the amino terminus of human Bcl9L
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anti-B-Cell CLL/lymphoma 9-Like (BCL9L) (AA 606-751) antibody
BCL9L 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1C9G2 unconjugated
anti-B-Cell CLL/lymphoma 9-Like (BCL9L) (AA 606-751) antibodyBCL9L 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 3B9C1 unconjugated
anti-B-Cell CLL/lymphoma 9-Like (BCL9L) (AA 147-176), (N-Term) antibodyBCL9L 适用: 人 WB 宿主: 兔 Polyclonal RB41624 unconjugated
anti-B-Cell CLL/lymphoma 9-Like (BCL9L) (N-Term) antibodyBCL9L 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- BCL9L (B-Cell CLL/lymphoma 9-Like (BCL9L))
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别名
- Bcl-9-Like Protein
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背景
- Bcl9L, a homolog of Bcl9, was initially identified through a bioinformatics screening. It is expressed in fetal brain, adult lung, eye and prostate, in addition to several types of tumors including pancreatic and prostate cancers. Bcl9L has been shown to interact with b-catenin, a target of the Wnt signaling pathway, and is required for enhanced ?-catenin-T-cell factor (TCF)-mediated transcription in colorectal tumor cells, possibly by translocating b-catenin to the nucleus. Other studies have indicated that Bcl9L expression correlates with high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers, suggesting that activity may occur in other types of cancer. Bcl9L has also been shown to be critical for Wnt-mediate regulation of stem cell traits in colon epithelium and adenocarcinomas which are associated with tumor invasion, metastasis, and resistance to therapy.Synonyms: B-cell CLL/lymphoma 9-like protein, B-cell lymphoma 9-like protein, BCL9-like protein, BCL9L, DLNB11
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基因ID
- 283149
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NCBI登录号
- NP_872363
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UniProt
- Q86UU0
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途径
- Stem Cell Maintenance
抗原
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