This antibody detects OGFOD1 at C-term. OGFOD1 antibody is predicted to not cross-react with other TPA1 protein family members. At least two isoforms are known to exist, this antibody will only detect the larger isform.
交叉反应 (详细)
Species reactivity (tested):Human, mouse
纯化方法
Affinity chromatography purified via peptide column
免疫原
18 amino acid peptide near the carboxy terminus of human OGFOD1
OGFOD1, a member of the 2-OG-Fe(II) dioxygenase family, plays an important role in ischemic survival and stress. It is an oxidoreductase containing a Prolyl 4-hydroxylase alpha subunit. An OGFOD1 iron binding residue is required for ATPAF1 gene expression. As a novel stress granule component, OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells.Synonyms: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, FLJ10826, KIAA1612, TPA1, Termination and polyadenylation 1 homolog