LRRTM3 抗体 (C-Term)
The 兔 多克隆 anti-LRRTM3 antibody is suitable to detect LRRTM3 in samples from 小鼠, 人 和 大鼠. It has been validated for WB 和 EIA.
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产品编号 ABIN783383
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Quick Overview for LRRTM3 抗体 (C-Term) (ABIN783383)
抗原
See all LRRTM3 抗体
LRRTM3
(Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))
适用
小鼠, 人, 大鼠
宿主
兔
克隆类型
多克隆
标记
This LRRTM3 antibody is un-conjugated
应用范围
Western Blotting (WB), Enzyme Immunoassay (EIA)
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抗原表位
- C-Term
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特异性
- This antibnody detects LRRTM3 at C-term. At least two isoforms of LRRTM3 are known to exist, this antibody will only detect the larger isoform.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 18 amino acid peptide near the carboxy terminus of human LRRTM3
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))
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别名
- LRRTM3
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背景
- The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the β-secretase BACE, leading to the proteolytic production of the Aβ42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Aβ42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.Synonyms: Leucine-rich repeat transmembrane neuronal protein 3
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基因ID
- 26045
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NCBI登录号
- NP_056379
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UniProt
- Q86VH5
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途径
- Synaptic Membrane
抗原
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