ZBTB4 抗体 (C-Term)
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Quick Overview for ZBTB4 抗体 (C-Term) (ABIN783355)
抗原
See all ZBTB4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects ZBTB4 (C-term). At least four isoforms of ZBTB4 are known to exist, this antibody will only recognize the longest isoform. This antibody is predicted to not cross-react with other ZBTB protein family members.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 18 amino acid peptide near the carboxy terminus of human ZBTB4
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anti-Zinc Finger and BTB Domain Containing 4 (ZBTB4) (AA 791-840) antibody
ZBTB4 适用: 人, 小鼠, 兔, 犬, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 4 (ZBTB4) (C-Term) antibodyZBTB4 适用: 人, 兔, 马, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger and BTB Domain Containing 4 (ZBTB4) antibodyZBTB4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- ZBTB4 (Zinc Finger and BTB Domain Containing 4 (ZBTB4))
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别名
- ZBTB4
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背景
- The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions, this degradation increases with DNA damage.Synonyms: KAISO-L1, KAISO-like zinc finger protein 1, KIAA1538, Zinc finger and BTB domain-containing protein 4
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基因ID
- 57659
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NCBI登录号
- NP_001122305
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UniProt
- Q9P1Z0
抗原
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