CDK5 抗体
(1 reference)Quick Overview for CDK5 抗体 (ABIN782438)
抗原
See all CDK5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Specific for the ~ 28 kDa Cdk5 protein in Western blots of Rat striatal lysate. The antibody shows no cross reactivity with the CDK5 cofactor p35 or its degradation product p25.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse, Rat.
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纯化方法
- Protein G Chromatography.
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免疫原
- Purified Rat Cdk5.
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亚型
- IgG
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anti-Cyclin-Dependent Kinase 5 (CDK5) antibody
CDK5 适用: 人, 大鼠, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 4E4 unconjugated
anti-Cyclin-Dependent Kinase 5 (CDK5) (AA 1-292) antibodyCDK5 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 5 (CDK5) (AA 15-100) antibodyCDK5 适用: 人, 小鼠, 大鼠 WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 5 (CDK5) (AA 1-292) antibodyCDK5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 5 (CDK5) antibodyCDK5 适用: 人, 小鼠 WB, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 1552CT262-105-8 unconjugated
anti-Cyclin-Dependent Kinase 5 (CDK5) (AA 1-292) antibodyCDK5 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 5 (CDK5) (AA 254-289) antibodyCDK5 适用: 人, 小鼠 WB, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 5 (CDK5) (Tyr15) antibodyCDK5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 5 (CDK5) (AA 254-289), (C-Term) antibodyCDK5 适用: 人, 小鼠 WB, FACS, IF 宿主: 兔 Polyclonal RB50850 unconjugated
anti-Cyclin-Dependent Kinase 5 (CDK5) (AA 1-292) antibodyCDK5 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody undiluted (in aliquots) at -20 °C.
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: "The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35." in: Molecular biology of the cell, Vol. 27, Issue 21, pp. 3221-3232, (2017) (PubMed).
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: "The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35." in: Molecular biology of the cell, Vol. 27, Issue 21, pp. 3221-3232, (2017) (PubMed).
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- CDK5 (Cyclin-Dependent Kinase 5 (CDK5))
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别名
- CDK5
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背景
- The neuronal protein kinase, Cdk5 has been implicated in a vast array of normal neuronal functions including regulation of neurotransmitter synthesis (Kansy J et al., 2004), the presynaptic vesicle cycle (Nguyen, C. & Bibb, JA 2003), neurotransmitter receptor trafficking and dopamine neurotransmission (Bibb, JA et al. 1999). At the same time Cdk5 has been implicated in a plethora of neurological and neuropsychiatric disorders including Alzheimer's, Parkinson's, Huntington's, epilepsy, schizophrenia, and drug addiction. Detection of Cdk5 in normal samples as well as tissue undergoing neurodegeneration may advance studies in these areas. Moreover, this antibody may allow more accurate postmortem evaluations of Cdk5 protein expression, and thus serve as a valuable new reagent for neuropathology.Synonyms: Cell division protein kinase 5, Cyclin-dependent kinase 5, PSSALRE, Serine/threonine-protein kinase PSSALRE, TPKII catalytic subunit, Tau protein kinase II catalytic subunit
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基因ID
- 140908
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NCBI登录号
- NP_543161
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UniProt
- Q03114
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途径
- Cell Division Cycle, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
抗原
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