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EBI3 抗体

IL-27b 适用: 人, 小鼠 WB, IHC (p) 宿主: 大鼠 Monoclonal DNT27 unconjugated
产品编号 ABIN781990
发货至: 中国
  • 抗原 See all EBI3 (IL-27b) 抗体
    EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))
    适用
    • 59
    • 15
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    人, 小鼠
    宿主
    • 54
    • 8
    • 3
    • 1
    大鼠
    克隆类型
    • 56
    • 10
    单克隆
    标记
    • 32
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    • 1
    • 1
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    This EBI3 antibody is un-conjugated
    应用范围
    • 43
    • 31
    • 18
    • 13
    • 13
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    The monoclonal antibody DNT27 reacts with Mouse Epstein-Barr Virus-induced gene 3 (EBI3).
    交叉反应 (详细)
    Species reactivity (tested):Human and Mouse.
    纯化方法
    Affinity Chromatography
    克隆位点
    DNT27
    亚型
    IgG2a
    Top Product
    Discover our top product IL-27b Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffer containing 0.09 % Sodium Azide and stabilizer if necessary
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))
    别名
    EBI3 / IL27B (IL-27b 产品)
    别名
    IL-27B antibody, IL27B antibody, EBI3 antibody, il-27rb antibody, si:dkey-97a13.4 antibody, EBI-3 antibody, IL-27 antibody, Epstein-Barr virus induced 3 antibody, Epstein-Barr virus induced gene 3 antibody, EBI3 antibody, ebi3 antibody, Ebi3 antibody
    物质类
    Viral Protein
    背景
    EBI3 is a 229 amino acid cytokine belonging to the type I cytokine receptor family (type 3 subfamily) with a signal peptide, 2 potential N-linked glycosylation sites, an LSDWS motif, 2 fibronectin type-III domains. It is usually induced due to infection of B lymphocytes by Epstein-Barr virus and due to expression of an EBV encoded latent membrane protein. EBI3 is a subunit of two heterodimeric cytokines interleukin-27 (IL27) and IL35. It is a secreted glycoprotein associated with calnexin and is a heterodimer with an alpha and a beta subunit. It is also known to interact with SQSTM1 and is responsible for the rapid clonal expansion of naive but not memory CD4 (+) T-cells. It strongly synergizes with IL-12 and trigger IFN-gamma production of naive CD4 (+) T-cells. It mediates its biologic effects through the cytokine receptor WSX-1/TCCR. It triggers signaling in T cells, B cells, and myeloid cells and along with p35 it acts as an important immunomodulator. It is usually expressed in various hemopoietic tissues and cell lines.Synonyms: EBV-induced gene 3 protein, Epstein-Barr virus-induced gene 3 protein, IL-27 subunit beta, IL-27B, Interleukin-27 subunit beta
    基因ID
    50498
    NCBI登录号
    NP_056581
    UniProt
    O35228
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