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Selectin E/CD62e 抗体 (FITC)

SELE 适用: 人 FACS 宿主: 大鼠 Monoclonal 4D10 FITC
产品编号 ABIN781710
发货至: 中国
  • 抗原 See all Selectin E/CD62e (SELE) 抗体
    Selectin E/CD62e (SELE) (Selectin E (SELE))
    适用
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    大鼠
    克隆类型
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    单克隆
    标记
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    This Selectin E/CD62e antibody is conjugated to FITC
    应用范围
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    Flow Cytometry (FACS)
    特异性
    This antibody detects CD62E / E-Selectin.
    交叉反应 (详细)
    Species reactivity (tested):Human
    纯化方法
    Affinity chromatography
    免疫原
    LPS-stimulated human endothelial cells
    克隆位点
    4D10
    亚型
    IgG2a
    Top Product
    Discover our top product SELE Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate buffered saline pH 7.2 (PBS), 10 mg/mL bovine serum albumin (BSA) as a stabilizer and 0.09 % sodium azide as a preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • 抗原
    Selectin E/CD62e (SELE) (Selectin E (SELE))
    别名
    CD62E / E-Selectin (SELE 产品)
    别名
    SELE antibody, CD62E antibody, ELAM antibody, ELAM1 antibody, ESEL antibody, LECAM2 antibody, E-selectin antibody, Elam antibody, selectin E antibody, selectin, endothelial cell antibody, SELE antibody, Sele antibody
    背景
    CD62E belongs to the selectin family and is thought to mediate rolling of myeloid cells and a subset of memory T cells on activated endothelium. The antigen is a 589 amino acid transmembrane protein. It consists of a C-type lectin-like domain, an epidermal growth factor (EGF)-like domain, six short consensus repeat (SCR) domains, a transmembrane domain and a cytoplasmic tail. CD62E is a counter-receptor for sialyl Lewis X, sialyl Lewis a and CLA (cutaneous lymphocyte antigen). It is involved in adhesion between myeloid cells and activated endothelium, and supports leucocytes rolling. Some skin-associated memory T cells express CLA, and it may be that CD62E is also involved in their homing to cutaneous sites of chronic inflammation. In addition, CD62E may also be involved in tumour metastasis. A soluble form of CD62E has been reported to mediate angiogenesis in pathological disorders.Synonyms: CD62 antigen-like family member E, ELAM1, Endothelial leukocyte adhesion molecule 1, LECAM2, Leukocyte-endothelial cell adhesion molecule 2, SELE
    基因ID
    6401
    NCBI登录号
    NP_000441
    UniProt
    P16581
    途径
    Thromboxane A2 Receptor Signaling
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