SOCS3 抗体
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北京 101111
Quick Overview for SOCS3 抗体 (ABIN781165)
抗原
See all SOCS3 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Protein G-Sepharose affinity purified.
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免疫原
- Recombinant fragment of Human SOCS3 (N-terminus).
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亚型
- IgG
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应用备注
- Recommended dilutions. ELISA: 1/5000 - 1/20000. WB: 1/100-1/2000.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 50µg/50µl
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缓冲液
- 0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))
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别名
- SOCS3
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背景
- SOCS3 is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity and thereby suppressing cytokine signaling. It is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. The expression of the SOCS3 gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. Studies of the mouse counterpart of the SOCS3 gene suggested this gene is involved in the negative regulation of fetal liver hematopoiesis, and placental development.
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分子量
- 45kDa
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NCBI登录号
- NM_003955
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途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C
抗原
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