RAB5 抗体 (AA 8-100) (HRP)
Quick Overview for RAB5 抗体 (AA 8-100) (HRP) (ABIN763535)
抗原
See all RAB5 (RAB5A) 抗体适用
宿主
克隆类型
标记
应用范围
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    - 
                                            抗原表位
- AA 8-100
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                                            交叉反应
- 小鼠
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                                            预测反应
- Human,Rat,Dog,Cow,Horse,Chicken,Rabbit
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                                            纯化方法
- Purified by Protein A.
- 
                                            免疫原
- KLH conjugated synthetic peptide derived from human RAB5.
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                                            亚型
- IgG
 
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    - 
                                            应用备注
- 
                        WB 1:300-5000
 IHC-P 1:200-400
 IHC-F 1:100-500
- 
                                            限制
- 仅限研究用
 
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    - 
                                            状态
- Liquid
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                                            浓度
- 1 μg/μL
- 
                                            缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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                                            储存液
- ProClin
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                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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                                            注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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                                            储存条件
- -20 °C
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                                            储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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                                            有效期
- 12 months
 
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    - RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))
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                                            别名
- RAB5
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                                            背景
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                        Synonyms: RAB 5, RAB 5A, RAB5A, RAB5A member RAS oncogene family, RAB5A_HUMAN, RAS associated protein RAB5A, Ras related protein Rab 5A, Ras-related protein Rab-5A. Background: Rab5-related subfamily. This subfamily includes Rab5 and Rab22 of mammals, Ypt51/Ypt52/Ypt53 of yeast, and RabF of plants. The members of this subfamily are involved in endocytosis and endocytic-sorting pathways. In mammals, Rab5 GTPases localize to early endosomes and regulate fusion of clathrin-coated vesicles to early endosomes and fusion between early endosomes. In yeast, Ypt51p family members similarly regulate membrane trafficking through prevacuolar compartments. GTPase activating proteins (GAPs) interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C-terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins. Due to the presence of truncated sequences in this CD, the lipid modification site is not available for annotation. 
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                                            基因ID
- 5868
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                                            途径
- Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity
 抗原
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