Titin 抗体 (AA 161-210)
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Quick Overview for Titin 抗体 (AA 161-210) (ABIN8125223)
抗原
See all Titin (TTN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 161-210
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原理
- TTN Antibody
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特异性
- The antibody detects endogenous TTN
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthetic peptide from human protein at AA range: 161-210
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亚型
- IgG
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应用备注
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Titin (TTN)
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别名
- TTN
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背景
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Synonyms: Titin (EC 2.7.11.1, Connectin, Rhabdomyosarcoma antigen MU-RMS-40.14)
Background: This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes.
Gene Name: TTN
Protein Name: Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)
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基因ID
- 7273
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UniProt
- Q8WZ42
抗原
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