SH3PXD2A 抗体
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北京 101111
Quick Overview for SH3PXD2A 抗体 (ABIN8124652)
抗原
See all SH3PXD2A 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Fish Antibody
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特异性
- Fish Polyclonal Antibody detects endogenous levels of Fish protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from the N-terminal region of human Fish.
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亚型
- IgG
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anti-SH3 and PX Domains 2A (SH3PXD2A) antibody
SH3PXD2A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SH3 and PX Domains 2A (SH3PXD2A) (AA 1-1105) antibodySH3PXD2A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- IHC 1:100-500,IF ICC 1:100-500,WB 1:500-2000,ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- SH3PXD2A (SH3 and PX Domains 2A (SH3PXD2A))
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别名
- Fish
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背景
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Synonyms: SH3PXD2A, FISH, KIAA0418, SH3MD1, TKS5, SH3 and PX domain-containing protein 2A, Adapter protein TKS5, Five SH3 domain-containing protein, SH3 multiple domains protein 1, Tyrosine kinase substrate with five SH3 domains
Background: domain:The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19.,domain:The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2).,function:Required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2). In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.,PTM:Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SH3PXD2 family.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 5 SH3 domains.,subcellular location:Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.,subunit:Interacts with ADAM12, ADAM15 and ADAM19.,tissue specificity:Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.,
Gene Name: SH3PXD2A
Protein Name: SH3 and PX domain-containing protein 2A
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基因ID
- 9644
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UniProt
- Q5TCZ1
抗原
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