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RNF144B 抗体

The 兔 多克隆 anti-RNF144B antibody is suitable to detect RNF144B in samples from 人 和 小鼠. It has been validated for WB 和 ELISA.
产品编号 ABIN8124438
发货至: 中国
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北京 101111
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Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for RNF144B 抗体 (ABIN8124438)

抗原

See all RNF144B 抗体
RNF144B (Ring Finger Protein 144B (RNF144B))

适用

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人, 小鼠

宿主

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兔

克隆类型

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多克隆

标记

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This RNF144B antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA
  • 原理

    p53RFP Antibody

    特异性

    P53RFP Polyclonal Antibody detects endogenous levels of p53RFP protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    免疫原

    Synthesized peptide derived from the Internal region of human p53RFP.

    亚型

    IgG
  • 应用备注

    WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    RNF144B (Ring Finger Protein 144B (RNF144B))

    别名

    p53RFP

    背景

    Synonyms: RNF144B, IBRDC2, P53RFP, E3 ubiquitin-protein ligase RNF144B, IBR domain-containing protein 2, RING finger protein 144B, p53-inducible RING finger protein

    Background: caution:Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.,domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.,function:E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism.,pathway:Protein modification, protein ubiquitination.,PTM:Auto-ubiquitinated.,similarity:Belongs to the RBR family. RNF144 subfamily.,similarity:Contains 1 IBR-type zinc finger.,similarity:Contains 2 RING-type zinc fingers.,subunit:Interacts with UBE2L3, UBE2L6 and LCMT2.,tissue specificity:Broadly expressed, with lowest levels in brain, spleen and thymus.,

    Gene Name: RNF144B

    Protein Name: E3 ubiquitin-protein ligase RNF144B

    基因ID

    255488

    UniProt

    Q7Z419
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