RAD9A 抗体 (pSer272)
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北京 101111
Quick Overview for RAD9A 抗体 (pSer272) (ABIN8124223)
抗原
See all RAD9A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer272
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原理
- RAD9 (Phospho Ser272) Antibody
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特异性
- This antibody detects endogenous levels of Human RAD9 (Phospho Ser272)
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human RAD9 (Phospho Ser272)
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亚型
- IgG
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anti-RAD9 Homolog A (S. Pombe) (RAD9A) (AA 162-391) antibody
RAD9A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAD9 Homolog A (S. Pombe) (RAD9A) (Center) antibodyRAD9A 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD9 Homolog A (S. Pombe) (RAD9A) (AA 1-389) antibodyRAD9A 适用: 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-RAD9 Homolog A (S. Pombe) (RAD9A) (pSer328) antibodyRAD9A 适用: 人 WB, IHC (p), DB 宿主: 兔 Polyclonal RB7115 unconjugated
anti-RAD9 Homolog A (S. Pombe) (RAD9A) antibodyRAD9A 适用: 人, 猴, 犬 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5D9 unconjugated
anti-RAD9 Homolog A (S. Pombe) (RAD9A) (pSer272) antibodyRAD9A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7109 unconjugated
anti-RAD9 Homolog A (S. Pombe) (RAD9A) (AA 1-30) antibodyRAD9A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0965-RB0966 unconjugated
anti-RAD9 Homolog A (S. Pombe) (RAD9A) (AA 365-391) antibodyRAD9A 适用: 人 WB, IHC (p), IF 宿主: 兔 Polyclonal RB29524 unconjugated
anti-RAD9 Homolog A (S. Pombe) (RAD9A) antibodyRAD9A 适用: 人, 小鼠 WB, IP 宿主: 小鼠 Monoclonal unconjugated
anti-RAD9 Homolog A (S. Pombe) (RAD9A) (AA 29-62), (N-Term) antibodyRAD9A 适用: 小鼠 WB 宿主: 兔 Polyclonal RB52362 unconjugated
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应用备注
- WB 1:1000-2000 ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- RAD9A (RAD9 Homolog A (S. Pombe) (RAD9A))
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别名
- RAD9
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背景
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Background: catalytic activity:Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.,function:Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.,PTM:Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.,similarity:Belongs to the rad9 family.,subunit:Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC complex. RAD9A interacts with BCL2L1, FEN1, PRKCD, RAD9B, HUS1, RAD1, ABL1, RPA1, ATAD5 and RPA2.,
Gene Name: RAD9
Protein Name: RAD9 (Phospho Ser272)
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UniProt
- Q96C41
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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