PAOX 抗体 (AA 260-340)
Our Local Distributor
北京 101111
Quick Overview for PAOX 抗体 (AA 260-340) (ABIN8123848)
抗原
See all PAOX 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 260-340
-
原理
- PAOX Antibody
-
特异性
- PAOX Polyclonal Antibody detects endogenous levels of PAOX protein.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
免疫原
- Synthesized peptide derived from PAOX . at AA range: 260-340
-
亚型
- IgG
-
-
-
-
应用备注
- WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:40000.. IF 1:50-200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C/1 year
-
有效期
- 12 months
-
-
- PAOX (Polyamine Oxidase (Exo-N4-Amino) (PAOX))
-
别名
- PAOX
-
背景
-
Synonyms: PAOX, PAO, Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, Polyamine oxidase
Background: catalytic activity:N(1),N(12)-diacetylspermine + O(2) + H(2)O = N(1)-acetylspermidine + 3-acetamidobutanal + H(2)O(2).,catalytic activity:N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2).,catalytic activity:N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2).,cofactor:Binds 1 FAD per subunit.,function:Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.,induction:By polyamine analogs.,miscellaneous:Oxidizes N(1)-acetylated polyamines on the exo-side of their N(4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N(4)-nitrogen.,pathway:Amine and polyamine metabolism, spermine metabolism.,similarity:Belongs to the flavin monoamine oxidase family.,subunit:Monomer.,tissue specificity:Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.,
Gene Name: PAOX
Protein Name: Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
-
基因ID
- 196743
-
UniProt
- Q6QHF9
抗原
-