Oncostatin M Receptor 抗体 (AA 501-550)
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Quick Overview for Oncostatin M Receptor 抗体 (AA 501-550) (ABIN8123515)
抗原
See all Oncostatin M Receptor (OSMR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 501-550
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原理
- IL-31RB Antibody
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特异性
- This antibody detects endogenous levels of Human IL-31RB
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from human IL-31RB AA range: 501-550
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亚型
- IgG
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anti-Oncostatin M Receptor (OSMR) (AA 503-749) antibody
OSMR 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Oncostatin M Receptor (OSMR) (AA 1-342) antibodyOSMR 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Oncostatin M Receptor (OSMR) (AA 1-342) antibodyOSMR 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Oncostatin M Receptor (OSMR) (Internal Region) antibodyVerified OSMR 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Oncostatin M Receptor (OSMR) (AA 120-193) antibodyOSMR 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Oncostatin M Receptor (OSMR) (AA 513-760) antibodyOSMR 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Oncostatin M Receptor (OSMR) (AA 410-652) antibodyOSMR 适用: 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Oncostatin M Receptor (OSMR) (AA 141-240) antibodyOSMR 适用: 人 WB 宿主: 小鼠 Monoclonal 3E12 unconjugated
anti-Oncostatin M Receptor (OSMR) antibodyOSMR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-2000 ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Oncostatin M Receptor (OSMR)
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别名
- IL-31RB
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背景
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Synonyms: Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB)
Background: disease:Defects in OSMR are the cause of amyloidosis type 9 (AMYL9) [MIM:105250], also known as primary cutaneous amyloidosis (PCA), primary localized cutaneous amyloidosis (PLCA), familial lichen amyloidosis or familial cutaneous lichen amyloidosis. AMYL9 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.,induction:Activated by oncostatin-M. Up-regulated by IFNG and lipopolysaccharide.,similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily.,similarity:Contains 4 fibronectin type-III domains.,subunit:Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.,tissue specificity:Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.,
Gene Name: OSMR OSMRB
Protein Name: IL-31RB
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基因ID
- 9180
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UniProt
- Q99650
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途径
- JAK/STAT Signaling, Growth Factor Binding
抗原
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