Cytochrome b 抗体 (AA 331-380)
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Quick Overview for Cytochrome b 抗体 (AA 331-380) (ABIN8122978)
抗原
See all Cytochrome b (MT-CYB) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 331-380
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原理
- Cytochrome b Antibody
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特异性
- Cytochrome b Polyclonal Antibody detects endogenous levels of Cytochrome b
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from human Cytochrome b. at AA range: 331-380
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亚型
- IgG
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anti-Mitochondrially Encoded Cytochrome B (MT-CYB) (AA 1-100) antibody
MT-CYB 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrially Encoded Cytochrome B (MT-CYB) (AA 201-228) antibodyMT-CYB 适用: 人 WB 宿主: 兔 Polyclonal RB23525 unconjugated
anti-Mitochondrially Encoded Cytochrome B (MT-CYB) (N-Term) antibodyMT-CYB 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrially Encoded Cytochrome B (MT-CYB) antibodyMT-CYB 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrially Encoded Cytochrome B (MT-CYB) (N-Term) antibodyMT-CYB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-2000, ELISA 1:10000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Cytochrome b (MT-CYB) (Mitochondrially Encoded Cytochrome B (MT-CYB))
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别名
- Cytochrome b
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背景
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Synonyms: Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit)
Background: cofactor:Binds 2 heme groups non-covalently.,disease:Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder).,disease:Defects in MT-CYB are the cause of cardiomyopathy infantile histiocytoid (CMIH) [MIM:500000]. CMIH is characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest, and the clinical course is usually fulminant, sometimes simulating sudden infant death syndrome.,disease:Defects in MT-CYB contribute to Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.,function:Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.,miscellaneous:Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.,similarity:Belongs to the cytochrome b family.,subunit:The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).,
Gene Name: MT-CYB
Protein Name: Cytochrome b
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基因ID
- 4519
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UniProt
- P00156
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途径
- Proton Transport
抗原
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