MMP1 抗体 (Cleaved-Ile271)
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北京 101111
Quick Overview for MMP1 抗体 (Cleaved-Ile271) (ABIN8122794)
抗原
See all MMP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Cleaved-Ile271
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原理
- MMP1 (Cleaved-Ile271) Antibody
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特异性
- This antibody detects endogenous levels of Human MMP1 (Cleaved-Ile271, protein was cleaved amino acid sequence between 270-271 )
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human MMP1 (Cleaved-Ile271)
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亚型
- IgG
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anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) antibody
MMP1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) antibodyMMP1 适用: 人 IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 6A5 unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 1-469) antibodyMMP1 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 20-280) antibodyMMP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 169-464) antibodyMMP1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (N-Term) antibodyMMP1 适用: 人, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 1-469) antibodyMMP1 适用: 人 WB, IHC (p), PLA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 124-469) antibodyMMP1 适用: 人 WB, IHC, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 317-347) antibodyMMP1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) (AA 98-275) antibodyMMP1 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- MMP1 (Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1))
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别名
- MMP1
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背景
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Synonyms: Interstitial collagenase (EC 3.4.24.7, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1) [Cleaved into: 22 kDa interstitial collagenase, 27 kDa interstitial collagenase]
Background: catalytic activity:Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,domain:There are two distinct domains in this protein, the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).,enzyme regulation:Can be activated without removal of the activation peptide.,function:Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.,online information:Collagenase entry,PTM:Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subunit:Interacts with HIV-1 Tat.,
Gene Name: MMP1 CLG
Protein Name: MMP1 (Cleaved-Ile271)
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基因ID
- 4312
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UniProt
- P03956
抗原
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