ITGA6 抗体 (Cleaved-Arg938, Heavy Chain)
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Quick Overview for ITGA6 抗体 (Cleaved-Arg938, Heavy Chain) (ABIN8122271)
抗原
See all ITGA6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Cleaved-Arg938, Heavy Chain
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原理
- ITGA6 (heavy chain, Cleaved-Arg938) Antibody
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特异性
- This antibody detects endogenous levels of Human ITGA6 (heavy chain, Cleaved-Arg938, protein was cleaved amino acid sequence between 938-939 )
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human ITGA6 (heavy chain, Cleaved-Arg938)
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亚型
- IgG
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anti-Integrin, alpha 6 (ITGA6) (Internal Region) antibody
ITGA6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 6 (ITGA6) antibodyITGA6 适用: 人 WB, FACS, IHC, ELISA, IF 宿主: 小鼠 Monoclonal 129CT49-6-5 unconjugated
anti-Integrin, alpha 6 (ITGA6) (AA 1082-1110), (C-Term) antibodyITGA6 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18006 unconjugated
anti-Integrin, alpha 6 (ITGA6) (AA 1043-1072), (Isoform 2) antibodyITGA6 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB15309 unconjugated
anti-Integrin, alpha 6 (ITGA6) (Ser1064) antibodyITGA6 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 6 (ITGA6) antibodyITGA6 适用: 人, 小鼠, 犬, Pig, 绵羊, Cynomolgus FACS, IP, IHC (fro) 宿主: 大鼠 Monoclonal NKI-GoH3 unconjugated
anti-Integrin, alpha 6 (ITGA6) antibody (PE)ITGA6 适用: 大鼠 FACS 宿主: 小鼠 Monoclonal Mab-5A PE
anti-Integrin, alpha 6 (ITGA6) (AA 625-866) antibodyITGA6 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 6 (ITGA6) antibodyITGA6 适用: 人, 小鼠, 犬, Pig, 绵羊, Cow, 马, 兔, Cat, Non-Human Primate FACS, IP, IHC (fro), ICC 宿主: 大鼠 Monoclonal GoH3 unconjugated
anti-Integrin, alpha 6 (ITGA6) antibody (APC)ITGA6 适用: 人, 小鼠, 犬, Pig, 绵羊, Cow, 马, 兔, Cat, Non-Human Primate FACS 宿主: 大鼠 Monoclonal GoH3 APC
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应用备注
- WB 1:500-2000,IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ITGA6 (Integrin, alpha 6 (ITGA6))
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别名
- ITGA6
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背景
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Synonyms: Integrin alpha-6 (CD49 antigen-like family member F, VLA-6, CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain, Integrin alpha-6 light chain]
Background: alternative products:Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms,disease:Defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia (EB-PA) [MIM:226730], also known as aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive disease characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus.,function:Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.,PTM:Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21.,tissue specificity:Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines, they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).,
Gene Name: ITGA6
Protein Name: ITGA6 (heavy chain, Cleaved-Arg938)
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基因ID
- 3655
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UniProt
- P23229
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途径
- CXCR4-mediated Signaling Events, Brown Fat Cell Differentiation, Integrin Complex
抗原
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