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IMPA1 抗体 (AA 158-208)

The 兔 多克隆 anti-IMPA1 antibody is suitable to detect IMPA1 in samples from 人, 小鼠 和 大鼠. It has been validated for WB.
产品编号 ABIN8122209
发货至: 中国
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Quick Overview for IMPA1 抗体 (AA 158-208) (ABIN8122209)

抗原

See all IMPA1 抗体
IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

适用

  • 48
  • 27
  • 25
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 43
  • 5
兔

克隆类型

  • 44
  • 4
多克隆

标记

  • 20
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This IMPA1 antibody is un-conjugated

应用范围

  • 26
  • 16
  • 16
  • 13
  • 9
  • 8
  • 5
  • 2
  • 2
  • 1
Western Blotting (WB)
  • 抗原表位

    • 24
    • 1
    • 1
    • 1
    • 1
    AA 158-208

    原理

    IMPA1 Antibody

    特异性

    This antibody detects endogenous levels of IMPA1 at Human/Mouse/Rat

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    免疫原

    Synthesized peptide derived from human IMPA1 AA range: 158-208

    亚型

    IgG
  • 应用备注

    WB 1:500-2000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

    别名

    IMPA1

    背景

    Background: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014],

    Gene Name: IMPA1 IMPA

    Protein Name: IMPA1

    基因ID

    3612

    UniProt

    P29218
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