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H2AFZ 抗体 (H2A.ZK14ac)

The 兔 多克隆 anti-H2AFZ antibody is suitable to detect H2AFZ in samples from 人, 小鼠 和 大鼠. It has been validated for WB 和 ELISA.
产品编号 ABIN8121870
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for H2AFZ 抗体 (H2A.ZK14ac) (ABIN8121870)

抗原

See all H2AFZ 抗体
H2AFZ (H2A Histone Family, Member Z (H2AFZ))

适用

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人, 小鼠, 大鼠

宿主

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兔

克隆类型

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多克隆

标记

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This H2AFZ antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA
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    H2A.ZK14ac

    原理

    Histone H2A.Z (Acetyl Lys14) Antibody

    特异性

    This antibody detects endogenous levels of Human,Mouse,Rat Histone H2A.Z (Acetyl Lys14)

    纯化方法

    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

    免疫原

    Synthesized peptide derived from human Histone H2A.Z (Acetyl Lys14)

    亚型

    IgG
  • 应用备注

    WB 1:1000-2000 ELISA 1:5000-20000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    H2AFZ (H2A Histone Family, Member Z (H2AFZ))

    别名

    Histone H2A.Z

    背景

    Synonyms: Histone H2A.Z (H2A/z)

    Background: function:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.,mass spectrometry:Monoisotopic, not modified PubMed:16457589,PTM:Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.,PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.,PTM:Not phosphorylated.,similarity:Belongs to the histone H2A family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.,

    Gene Name: H2AFZ H2AZ

    Protein Name: Histone H2A.Z (Acetyl Lys14)

    基因ID

    3015

    UniProt

    P0C0S5

    途径

    Telomere Maintenance
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