GATA1 抗体 (acLys312)
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北京 101111
Quick Overview for GATA1 抗体 (acLys312) (ABIN8121619)
抗原
See all GATA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- acLys312
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原理
- GATA-1 (Acetyl Lys312) Antibody
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特异性
- This antibody detects endogenous levels of Human,Mouse,Rat GATA-1 (Acetyl Lys312)
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human GATA-1 (Acetyl Lys312)
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亚型
- IgG
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anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (Internal Region) antibody
Verified GATA1 适用: 人, 小鼠 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (AA 123-199) antibodyGATA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G6 unconjugated
anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) antibodyGATA1 适用: 人 WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 4F5 unconjugated
anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (AA 39-153) antibodyGATA1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (AA 1-413) antibodyGATA1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) antibodyGATA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G1 unconjugated
anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (pSer310) antibodyGATA1 适用: 人, 小鼠, 大鼠, 猴 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (pSer142) antibodyGATA1 适用: 人, 小鼠, 大鼠 WB, IHC, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (AA 20-265) antibodyGATA1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (pSer310) antibodyGATA1 适用: 人, 小鼠, 大鼠, 猴, 犬, Cow, 兔, 马 WB, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-2000 ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- GATA1 (GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1))
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别名
- GATA-1
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背景
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Synonyms: Erythroid transcription factor (Eryf1, GATA-binding factor 1, GATA-1, GF-1, NF-E1 DNA-binding protein)
Background: disease:Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.,disease:Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050], also called thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. The disease consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor.,domain:The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding.,function:Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells.,PTM:Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137.,PTM:Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation by SUMO1 has no effect on transcriptional activity.,similarity:Contains 2 GATA-type zinc fingers.,subunit:Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4, the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner.,tissue specificity:Erythrocytes.,
Gene Name: GATA1 ERYF1 GF1
Protein Name: GATA-1 (Acetyl Lys312)
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基因ID
- 2623
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UniProt
- P15976
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途径
- Cellular Response to Molecule of Bacterial Origin
抗原
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