GIT2 抗体 (pTyr592)
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Quick Overview for GIT2 抗体 (pTyr592) (ABIN8121561)
抗原
See all GIT2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr592
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原理
- GIT2 (Phospho Tyr592) Antibody
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特异性
- This antibody detects endogenous levels of Human GIT2 (phospho-Tyr592)
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized phosho peptide around human GIT2 (Tyr592)
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亚型
- IgG
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应用备注
- WB 1:1000-2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))
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别名
- GIT2
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背景
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Synonyms: ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
Background: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G
Gene Name: GIT2 KIAA0148
Protein Name: GIT2 (Tyr592)
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基因ID
- 9815
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UniProt
- Q14161
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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