FOXO4 抗体 (acLys407)
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北京 101111
Quick Overview for FOXO4 抗体 (acLys407) (ABIN8121514)
抗原
See all FOXO4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- acLys407
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原理
- FoxO4 (Acetyl Lys407) Antibody
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特异性
- This antibody detects endogenous levels of Human,Mouse FoxO4 (Acetyl Lys407)
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human FoxO4 (Acetyl Lys407)
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亚型
- IgG
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anti-Forkhead Box O4 (FOXO4) antibody
KD Validated FOXO4 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB1470 unconjugated Recombinant Antibody
anti-Forkhead Box O4 (FOXO4) (N-Term) antibodyFOXO4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) antibodyKO Validated FOXO4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3445 unconjugated Recombinant Antibody
anti-Forkhead Box O4 (FOXO4) (pSer197) antibodyFOXO4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) (AA 206-240) antibodyFOXO4 适用: 人 WB, IF 宿主: 兔 Polyclonal RB51229 unconjugated
anti-Forkhead Box O4 (FOXO4) (Internal Region) antibodyVerified FOXO4 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) (pSer197) antibodyFOXO4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) (AA 45-63) antibodyFOXO4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O4 (FOXO4) (AA 44-73), (N-Term) antibodyFOXO4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2253 unconjugated
anti-Forkhead Box O4 (FOXO4) (Internal Region) antibodyFOXO4 适用: 人, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal AFfirm8916 unconjugated
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应用备注
- WB 1:1000-2000 ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- FOXO4 (Forkhead Box O4 (FOXO4))
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别名
- FoxO4
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背景
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Synonyms: Forkhead box protein O4 (Fork head domain transcription factor AFX1)
Background: disease:A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X,11)(q13,q23) with MLL/HRX. The result is a rogue activator protein.,function:Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.,pharmaceutical:A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity.,PTM:Acetylation by CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity.,PTM:Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization.,similarity:Contains 1 fork-head DNA-binding domain.,subcellular location:When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.,subunit:Interacts with CBP, MYOCD, SIRT1, SRF and YWHAZ. Acetylated by CBP and deacetylated by SIRT1. Binding of YWHAZ inhibits DNA-binding.,tissue specificity:Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.,
Gene Name: FOXO4 AFX AFX1 MLLT7
Protein Name: FoxO4 (Acetyl Lys407)
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基因ID
- 4303
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UniProt
- P98177
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途径
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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