CRTC2 抗体 (pSer171)
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Quick Overview for CRTC2 抗体 (pSer171) (ABIN8120753)
抗原
See all CRTC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer171
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原理
- TORC2 (phospho Ser171) Antibody
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特异性
- This antibody detects endogenous levels of TORC2 Phospho-Ser171 at Human, Mouse,Rat
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human TORC2 Phospho-Ser171
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亚型
- IgG
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应用备注
- WB 1:500-2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
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别名
- TORC2
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背景
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Synonyms: CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)
Background: This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010],
Gene Name: CRTC2 TORC2
Protein Name: TORC2 Phospho-Ser171
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基因ID
- 200186
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UniProt
- Q53ET0
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途径
- AMPK Signaling, Carbohydrate Homeostasis
抗原
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