BCCIP 抗体 (AA 60-140)
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北京 101111
Quick Overview for BCCIP 抗体 (AA 60-140) (ABIN8120029)
抗原
See all BCCIP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 60-140
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原理
- TOK-1 Antibody
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特异性
- TOK-1 Polyclonal Antibody detects endogenous levels of TOK-1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from TOK-1 . at AA range: 60-140
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))
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别名
- TOK-1
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背景
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Synonyms: BCCIP, TOK1, BRCA2 and CDKN1A-interacting protein, P21- and CDK-associated protein 1, Protein TOK-1
Background: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Gene Name: BCCIP
Protein Name: BRCA2 and CDKN1A-interacting protein
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基因ID
- 56647
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UniProt
- Q9P287
抗原
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