BCL6 抗体 (AA 250-350)
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北京 101111
Quick Overview for BCL6 抗体 (AA 250-350) (ABIN8119946)
抗原
See all BCL6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 250-350
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原理
- Bcl-6 mouse mAb
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特异性
- This antibody detects endogenous levels of Bcl-6.
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纯化方法
- The antibody was purified by protein G affinity chromatography.
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免疫原
- A synthetic peptide corresponding to the amino acid region 250 - 350 of the human Bcl - 6 protein.
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亚型
- IgG
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应用备注
- WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze / thaw cycles
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储存条件
- -20 °C
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储存方法
- Store at-20°C. Avoid freeze / thaw cycles.
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- BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
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别名
- Bcl-6
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背景
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Synonyms: BCL6,BCL5,LAZ3,ZBTB27,ZNF51,B-cell lymphoma 6 protein,BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51
Background: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) , and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015],
Gene Name: BCL6 BCL5 LAZ3 ZBTB27 ZNF51
Protein Name: Bcl-6
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基因ID
- 604
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UniProt
- P41182
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途径
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus
抗原
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