ARNTL 抗体 (pSer42)
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Quick Overview for ARNTL 抗体 (pSer42) (ABIN8119813)
抗原
See all ARNTL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer42
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原理
- BMAL1 (Phospho Ser42) Antibody
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特异性
- This antibody detects endogenous levels of Human Mouse Rat BMAL1 (phospho-Ser42)
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized phosho peptide around human BMAL1 (Ser42)
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亚型
- IgG
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应用备注
- WB 1:1000-2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))
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别名
- BMAL1
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背景
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Synonyms: Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)
Background: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],
Gene Name: ARNTL BHLHE5 BMAL1 MOP3 PASD3
Protein Name: BMAL1 (Ser42)
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基因ID
- 406
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UniProt
- O00327
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途径
- Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Warburg Effect
抗原
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