ACER1 抗体 (AA 100-180)
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北京 101111
Quick Overview for ACER1 抗体 (AA 100-180) (ABIN8119660)
抗原
See all ACER1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 100-180
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原理
- ASAH3 Antibody
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特异性
- ASAH3 Polyclonal Antibody detects endogenous levels of ASAH3 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from ASAH3 . at AA range: 100-180
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亚型
- IgG
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anti-Alkaline Ceramidase 1 (ACER1) (Internal Region) antibody
ACER1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) antibodyACER1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) (AA 236-263), (C-Term) antibodyACER1 适用: 人 WB 宿主: 兔 Polyclonal RB37377 unconjugated
anti-Alkaline Ceramidase 1 (ACER1) (AA 141-190) antibodyACER1 适用: 人, 猴, Cow, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) (Internal Region) antibodyACER1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ACER1 (Alkaline Ceramidase 1 (ACER1))
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别名
- ASAH3
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背景
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Synonyms: ACER1, ASAH3, Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3
Background: Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081], Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010],
Gene Name: ACER1
Protein Name: Alkaline ceramidase 1
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基因ID
- 125981
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UniProt
- Q8TDN7
抗原
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