HIST1H3A 抗体 (AA 131-230) (FITC)
Quick Overview for HIST1H3A 抗体 (AA 131-230) (FITC) (ABIN759513)
抗原
See all HIST1H3A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 131-230
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交叉反应
- 人, 小鼠, 大鼠, 绵羊
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预测反应
- Dog,Cow,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human HIF3 alpha
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亚型
- IgG
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anti-Histone Cluster 1, H3a (HIST1H3A) (acLys27) antibody
HIST1H3A 适用: 人 ELISA, WB, IF, ICC, ChIP, IP 宿主: 兔 Polyclonal unconjugated
anti-Histone Cluster 1, H3a (HIST1H3A) antibodyHIST1H3A 适用: 人 ELISA, WB, IHC, IF, FACS 宿主: 兔 Monoclonal 27F2 unconjugated Recombinant Antibody
anti-Histone Cluster 1, H3a (HIST1H3A) (acLys4) antibodyHIST1H3A 适用: 人 ELISA, WB, IF, ChIP, IP 宿主: 兔 Polyclonal unconjugated
anti-Histone Cluster 1, H3a (HIST1H3A) (H3K4me2) antibodyHIST1H3A 适用: 人 ELISA, WB, IF, ICC, FACS 宿主: 兔 Monoclonal 6F6 unconjugated Recombinant Antibody
anti-Histone Cluster 1, H3a (HIST1H3A) (pSer10) antibodyHIST1H3A 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone Cluster 1, H3a (HIST1H3A) (H3K27me2) antibodyHIST1H3A 适用: 人 ELISA, WB, IF, ChIP, DB, FM 宿主: 兔 Polyclonal unconjugated
anti-Histone Cluster 1, H3a (HIST1H3A) (acLys9) antibodyHIST1H3A 适用: 人 ELISA, WB, ICC, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Histone Cluster 1, H3a (HIST1H3A) (acLys37) antibodyHIST1H3A 适用: 人 ELISA, WB, IF, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Histone Cluster 1, H3a (HIST1H3A) (acLys36) antibodyHIST1H3A 适用: 人 ELISA, WB, IF, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Histone Cluster 1, H3a (HIST1H3A) (acLys23) antibodyHIST1H3A 适用: 人 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- HIST1H3A (Histone Cluster 1, H3a (HIST1H3A))
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别名
- H3 alpha
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背景
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Synonyms: IPAS, MOP7, PASD7, HIF-3A, bHLHe17, Hypoxia-inducible factor 3-alpha, HIF-3-alpha, HIF3-alpha, Basic-helix-loop-helix-PAS protein MOP7, Class E basic helix-loop-helix protein 17, HIF3-alpha-1, Inhibitory PAS domain protein, Member of PAS protein 7, PAS domain-containing protein 7, HIF3A
Background: Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea (By similarity).
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基因ID
- 64344
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UniProt
- Q9Y2N7
抗原
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