UFC1 抗体 (AA 1-167)
Our Local Distributor
北京 101111
Quick Overview for UFC1 抗体 (AA 1-167) (ABIN8093547)
抗原
See all UFC1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-167
-
原理
- UFC1 Antibody / Ubiquitin-fold modifier conjugating enzyme 1
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human Ubiquitin-fold modifier conjugating enzyme 1 recombinant protein (amino acids M1-Q167) was used as the immunogen for the UFC1 antibody.
-
亚型
- IgG
-
-
anti-Ubiquitin-Fold Modifier Conjugating Enzyme 1 (UFC1) (C-Term) antibody
UFC1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB6527 unconjugated
anti-Ubiquitin-Fold Modifier Conjugating Enzyme 1 (UFC1) antibodyUFC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Fold Modifier Conjugating Enzyme 1 (UFC1) antibodyKD Validated UFC1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4245 unconjugated Recombinant Antibody
anti-Ubiquitin-Fold Modifier Conjugating Enzyme 1 (UFC1) (AA 2-31), (N-Term) antibodyUFC1 适用: 人 WB 宿主: 兔 Polyclonal RB40483 unconjugated
anti-Ubiquitin-Fold Modifier Conjugating Enzyme 1 (UFC1) (AA 1-167) antibodyUFC1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the UFC1 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the UFC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- UFC1 (Ubiquitin-Fold Modifier Conjugating Enzyme 1 (UFC1))
-
别名
- UFC1
-
背景
-
UFC1 antibody targets Ubiquitin-fold modifier conjugating enzyme 1, encoded by the UFC1 gene. Ubiquitin-fold modifier conjugating enzyme 1 is a cytoplasmic enzyme that functions as the E2 conjugating component of the UFM1 modification pathway, a ubiquitin-like system that regulates protein quality control and cellular stress responses. In this pathway, UFC1 accepts activated UFM1 from the E1 enzyme UBA5 and cooperates with the E3 ligase UFL1 to transfer UFM1 to specific substrate proteins, enabling ufmylation as a post-translational regulatory mechanism.
Functionally, Ubiquitin-fold modifier conjugating enzyme 1 plays an essential role in maintaining endoplasmic reticulum homeostasis and supporting cellular adaptation to proteotoxic stress. UFM1 conjugation mediated by UFC1 has been linked to ribosome-associated quality control, ER-associated protein processing, and regulation of secretory pathways. Through these activities, UFC1 helps coordinate cellular responses to disruptions in protein folding and trafficking. A UFC1 antibody supports studies examining ufmylation-dependent signaling and stress-regulated protein modification.
UFC1 is broadly expressed across many tissues and cell types, reflecting the fundamental requirement for UFM1-mediated regulation in diverse biological contexts. Its function is particularly relevant in cells with high secretory demand or elevated metabolic activity, where ER stress pathways must be precisely controlled. UFC1 operates within a dynamic enzyme complex, forming transient thioester-linked intermediates with UFM1 that enable controlled transfer to downstream targets.
From a disease-relevance perspective, dysregulation of the UFM1 conjugation system, including altered UFC1 activity, has been implicated in cancer, neurodevelopmental disorders, and inflammatory conditions. Impaired ufmylation can compromise ER integrity and protein homeostasis, contributing to pathological cellular states. As a result, Ubiquitin-fold modifier conjugating enzyme 1 has emerged as a protein of interest in studies of stress signaling and disease-associated protein modification pathways.
At the molecular level, UFC1 contains conserved catalytic residues characteristic of E2 enzymes that are required for UFM1 thioester bond formation. Its apparent behavior in biochemical assays can be influenced by interaction partners, enzymatic state, or cellular context. UFC1 antibody reagents support research applications focused on ufmylation biology, ER stress regulation, and protein quality control, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- Q9Y3C8
抗原
-
