Recombinant Selectin E/CD62e 抗体
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Quick Overview for Recombinant Selectin E/CD62e 抗体 (ABIN8093463)
抗原
See all Selectin E/CD62e (SELE) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- SELE Antibody / E-selectin (azide and preservative free)
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免疫原
- Prokaryotic recombinant fusion protein corresponding to the cysteine-rich complement control protein domains of the CD62E molecule was used as the immunogen for the SELE/E-selectin antibody.
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亚型
- IgG1, kappa
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anti-Selectin E (SELE) (AA 501-612) antibody
SELE 适用: 小鼠 WB, FACS, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Selectin E (SELE) (AA 22-230) antibodySELE 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Selectin E (SELE) (AA 22-555) antibodySELE 适用: 人 WB, IHC, IP, FACS, ICC 宿主: 兔 Monoclonal BLR295L unconjugated Recombinant Antibody
anti-Selectin E (SELE) antibodySELE 适用: 人 ELISA 宿主: 小鼠 Monoclonal B-P7 unconjugated
anti-Selectin E (SELE) antibodySELE 适用: 小鼠 WB, IHC, IP, ELISA, FACS, ICC, IHC (fro), Func 宿主: 大鼠 Monoclonal UZ5 unconjugated
anti-Selectin E (SELE) (AA 108-238) antibodySELE 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Selectin E (SELE) (AA 260-420) antibodySELE 适用: Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Selectin E (SELE) antibodySELE 适用: 人 WB 宿主: 兔 Polyclonal RB38827 unconjugated
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应用备注
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1. Optimal dilution of the SELE/E-selectin antibody should be determined by the researcher.
2. This SELE/E-selectin antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- SELE/E-selectin antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- Selectin E/CD62e (SELE) (Selectin E (SELE))
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别名
- SELE
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背景
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SELE antibody, also known as E-selectin antibody, recognizes E-selectin, a type I transmembrane adhesion molecule encoded by the SELE gene and commonly referred to as CD62E and endothelial-leukocyte adhesion molecule 1. E-selectin is primarily localized to the plasma membrane of activated endothelial cells and is a member of the selectin family of calcium-dependent lectins. Under basal conditions, SELE expression is low or absent, however, it is rapidly induced in endothelial cells in response to inflammatory cytokines such as interleukin-1 and tumor necrosis factor alpha, linking vascular activation to immune cell recruitment.
SELE antibody detects a glycoprotein composed of an N-terminal C-type lectin domain, an epidermal growth factor-like domain, multiple short consensus repeat units, a single transmembrane region, and a short cytoplasmic tail. The lectin domain mediates binding to sialylated carbohydrate ligands, including sialyl Lewis x structures on neutrophils, monocytes, and subsets of lymphocytes. Through these interactions, E-selectin supports leukocyte tethering and rolling along the vascular endothelium under shear flow conditions, representing a critical early step in extravasation during inflammation.
Functionally, E-selectin plays a central role in acute and chronic inflammatory responses by regulating leukocyte trafficking into tissues. Because its expression is tightly controlled and transient following cytokine stimulation, SELE is widely used as a marker of endothelial activation in experimental models of vascular inflammation. Elevated E-selectin levels have been associated with atherosclerosis, cardiovascular disease, autoimmune disorders, and other inflammatory conditions. In oncology research, endothelial E-selectin can contribute to adhesion of circulating tumor cells, implicating SELE in metastatic dissemination and tumor-vascular interactions.
The SELE gene is located on chromosome 1 and is transcriptionally regulated by inflammatory signaling pathways, including those downstream of nuclear factor kappa B activation. The endothelial-restricted and inducible nature of E-selectin expression makes detection of this protein valuable for studying cytokine signaling, vascular biology, and immune-endothelial interactions.
This recombinant monoclonal SELE antibody (clone r16G4) targets E-selectin protein in research applications. SELE antibody supports investigation of endothelial activation, leukocyte recruitment mechanisms, and disease-associated inflammatory signaling. -
UniProt
- P16581
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途径
- Thromboxane A2 Receptor Signaling
抗原
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