PDCD6 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for PDCD6 抗体 (N-Term) (ABIN8093426)
抗原
See all PDCD6 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- N-Term
-
原理
- PDCD6 Antibody / Programmed cell death protein 6
-
纯化方法
- Immunogen affinity purified
-
免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Programmed cell death protein 6 protein was used as the immunogen for the PDCD6 antibody.
-
亚型
- IgG
-
-
anti-Programmed Cell Death 6 (PDCD6) (AA 32-191) antibody
PDCD6 适用: 人 WB, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 6 (PDCD6) (AA 92-191) antibodyPDCD6 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2B4 unconjugated
anti-Programmed Cell Death 6 (PDCD6) (AA 1-191) antibodyPDCD6 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 6 (PDCD6) antibodyPDCD6 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 6 (PDCD6) (AA 1-191) antibodyPDCD6 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 6 (PDCD6) antibodyPDCD6 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 6 (PDCD6) (AA 19-47), (N-Term) antibodyPDCD6 适用: 人 WB 宿主: 兔 Polyclonal RB41816 unconjugated
anti-Programmed Cell Death 6 (PDCD6) (AA 103-137) antibodyPDCD6 适用: 小鼠 WB 宿主: 兔 Polyclonal RB49787 unconjugated
-
-
应用备注
- Optimal dilution of the PDCD6 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the PDCD6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- PDCD6 (Programmed Cell Death 6 (PDCD6))
-
别名
- PDCD6
-
背景
-
PDCD6 antibody targets Programmed cell death protein 6, encoded by the PDCD6 gene. Programmed cell death protein 6, also known as ALG-2, is a calcium-binding protein that belongs to the penta-EF-hand family. It is predominantly localized in the cytoplasm and nucleus and functions as a calcium-dependent signaling adaptor rather than a classical enzyme. PDCD6 was originally identified through its involvement in apoptosis-related pathways but is now recognized as a broader regulator of intracellular signaling and membrane trafficking.
Functionally, Programmed cell death protein 6 responds to changes in intracellular calcium levels and undergoes conformational changes that enable interactions with multiple partner proteins. Through these interactions, PDCD6 participates in processes such as apoptosis regulation, vesicle trafficking, and endosomal sorting. It has been shown to associate with components of the ESCRT machinery and other signaling proteins, linking calcium signaling to membrane dynamics. A PDCD6 antibody supports studies focused on calcium-dependent signaling and apoptotic regulation.
PDCD6 is widely expressed across tissues and cell types, reflecting its involvement in fundamental cellular processes. Its activity is particularly relevant in cells undergoing dynamic calcium signaling or stress responses. Subcellular localization of PDCD6 can vary depending on calcium availability and interacting partners, allowing it to act as a flexible signaling mediator within the cell.
From a disease-relevance perspective, Programmed cell death protein 6 has been investigated in cancer, immune regulation, and neurodegenerative conditions. Altered PDCD6 expression or signaling has been associated with changes in apoptosis sensitivity, tumor progression, and inflammatory responses. These findings highlight PDCD6 as a protein of interest in studies examining how calcium-dependent pathways influence disease-associated cellular behavior.
At the molecular level, Programmed cell death protein 6 contains multiple EF-hand motifs that coordinate calcium binding and protein-protein interactions. Calcium-dependent conformational changes and post-translational regulation can influence its apparent behavior in biochemical assays without altering the primary amino acid sequence. PDCD6 antibody reagents support research applications focused on apoptosis, calcium signaling, and intracellular trafficking, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- O75340
-
途径
- Positive Regulation of Endopeptidase Activity
抗原
-
