PRND 抗体 (AA 111-144)
The 兔 多克隆 anti-PRND antibody (ABIN8093424) specifically detects PRND in WB, ELISA, IHC, IF 和 FACS.
The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN8093424
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for PRND 抗体 (AA 111-144) (ABIN8093424)
抗原
See all PRND 抗体
PRND
(Prion Protein 2 (Dublet) (PRND))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This PRND antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
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抗原表位
- AA 111-144
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原理
- PRND Antibody / Prion-like protein doppel
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human Prion-like protein doppel recombinant protein (amino acids A111-H144) was used as the immunogen for the PRND antibody.
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亚型
- IgG
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anti-Prion Protein 2 (Dublet) (PRND) (AA 20-160) antibody
PRND 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Prion Protein 2 (Dublet) (PRND) antibodyPRND 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PRND antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PRND antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PRND (Prion Protein 2 (Dublet) (PRND))
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别名
- PRND
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背景
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PRND antibody targets Prion-like protein doppel, encoded by the PRND gene. Prion-like protein doppel is a glycosylphosphatidylinositol-anchored protein that shares structural similarity with the cellular prion protein, although it exhibits distinct expression patterns and biological functions. PRND is primarily localized to the cell surface, where it associates with lipid rafts and extracellular environments. Unlike the ubiquitously expressed prion protein, doppel expression is more restricted and shows strong tissue specificity.
Functionally, Prion-like protein doppel has been implicated in regulation of cell survival, differentiation, and tissue homeostasis. PRND is particularly associated with male reproductive biology, where it plays an important role in spermatogenesis and sperm function. Loss or dysregulation of PRND expression has been linked to impaired fertility, highlighting its physiological importance. A PRND antibody supports studies focused on reproductive biology and prion-related protein function.
PRND expression is most prominent in testicular tissue, with lower or tightly regulated expression reported in other tissues. Its membrane localization and glycosylation state contribute to its functional interactions with extracellular partners and signaling pathways. Because of its restricted expression profile, PRND is often used as a marker for studying tissue-specific regulation and differentiation states in reproductive systems.
From a disease-relevance perspective, Prion-like protein doppel has been investigated in the context of neurobiology and cancer. Aberrant expression of PRND has been reported in certain tumor types, where it may influence cell survival and tumor progression. In addition, due to its structural relationship with prion proteins, PRND is of interest in studies examining prion biology and protein misfolding mechanisms, although it is not itself associated with transmissible prion diseases.
At the molecular level, Prion-like protein doppel contains conserved domains involved in protein folding and membrane attachment through its GPI anchor. Post-translational modifications, including glycosylation, can influence its apparent molecular weight and behavior in biochemical assays without altering the primary amino acid sequence. PRND antibody reagents support research applications focused on reproductive biology, prion-related proteins, and disease-associated expression changes, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- Q9UKY0
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途径
- Transition Metal Ion Homeostasis
抗原
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