Recombinant PVRL4 抗体 (Extracellular)
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Quick Overview for Recombinant PVRL4 抗体 (Extracellular) (ABIN8093419)
抗原
See all PVRL4 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 266-280, Extracellular
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原理
- NECTIN4 Antibody / Poliovirus receptor related 4 (azide and preservative free)
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免疫原
- A recombinant fragment (around amino acids 266-280) of human NECTIN4 protein corresponding to the extracellular domain (exact sequence is proprietary) was used as the immunogen for the Poliovirus receptor related 4/NECTIN4 antibody.
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亚型
- IgG, kappa
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anti-Poliovirus Receptor-Related 4 (PVRL4) antibody
PVRL4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 91-199) antibodyPVRL4 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 151-250) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 84-96), (Extracellular), (N-Term) antibodyPVRL4 适用: 小鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 239-266) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal RB37608 unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 371-510) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) antibodyPVRL4 适用: 人 FACS 宿主: Human, 兔 Chimeric DMC438 unconjugated Fc fragment Recombinant Antibody
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 31-139) antibodyPVRL4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 1-510) antibodyPVRL4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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1. Optimal dilution of the Poliovirus receptor related 4/NECTIN4 antibody should be determined by the researcher.
2. This Poliovirus receptor related 4/NECTIN4 antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Poliovirus receptor related 4/NECTIN4 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
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别名
- NECTIN4
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背景
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Poliovirus receptor related 4 antibody, also known as NECTIN4 antibody, recognizes Poliovirus receptor related 4, a type I transmembrane cell adhesion molecule encoded by the NECTIN4 gene. Commonly referred to as Nectin-4 and also designated PVRL4, this protein is a member of the nectin family within the immunoglobulin superfamily. NECTIN4 localizes predominantly to the cell membrane at adherens junctions, where it participates in Ca2+-independent cell-cell adhesion and contributes to maintenance of epithelial tissue architecture. Poliovirus receptor related 4 antibody is widely used in studies of epithelial biology and tumor-associated membrane protein expression.
NECTIN4 contains three extracellular immunoglobulin-like domains, a single transmembrane segment, and a cytoplasmic tail that interacts with intracellular adaptor proteins involved in junctional organization and cytoskeletal linkage. Through homophilic and heterophilic interactions with other nectin family members, Poliovirus receptor related 4 regulates cell polarity, adhesion strength, and tissue integrity. In normal tissues, expression is relatively restricted, with detectable levels in skin, placenta, and certain epithelial compartments. During development, nectin family proteins contribute to tissue morphogenesis and coordinated cell positioning.
Aberrant overexpression of Nectin-4 has been documented in multiple malignancies, including urothelial carcinoma, breast cancer, lung cancer, and ovarian cancer. Elevated NECTIN4 expression has been associated with enhanced proliferation and tumor progression, and the protein has been explored as a surface biomarker in oncology research. Immunostaining typically demonstrates membranous localization in positive tumor cells, consistent with its function as a cell surface adhesion molecule. Clone NECTIN4/13438R is a recombinant rabbit monoclonal antibody generated through defined sequence expression, supporting consistency between production lots. This Poliovirus receptor related 4 antibody enables investigation of NECTIN4 expression in research applications focused on epithelial adhesion, tumor biology, and membrane-associated signaling pathways. -
UniProt
- Q96NY8
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途径
- Cell-Cell Junction Organization
抗原
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