PVRL4 抗体 (AA 1-200)
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北京 101111
Quick Overview for PVRL4 抗体 (AA 1-200) (ABIN8093417)
抗原
See all PVRL4 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-200
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原理
- NECTIN4 Antibody / Nectin cell adhesion molecule 4 (azide and preservative free)
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免疫原
- A recombinant fragment (around amino acids 1-200) of human NECTIN4 protein (exact sequence is proprietary) was used as the immunogen for the Nectin cell adhesion molecule 4/NECTIN4 antibody.
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亚型
- IgG1, kappa
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anti-Poliovirus Receptor-Related 4 (PVRL4) antibody
PVRL4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 91-199) antibodyPVRL4 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 151-250) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 84-96), (Extracellular), (N-Term) antibodyPVRL4 适用: 小鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 239-266) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal RB37608 unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 371-510) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) antibodyPVRL4 适用: 人 FACS 宿主: Human, 兔 Chimeric DMC438 unconjugated Fc fragment Recombinant Antibody
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 31-139) antibodyPVRL4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 1-510) antibodyPVRL4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Nectin cell adhesion molecule 4/NECTIN4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Nectin cell adhesion molecule 4/NECTIN4 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
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别名
- NECTIN4
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背景
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Nectin cell adhesion molecule 4 antibody, also known as NECTIN4 antibody, recognizes Nectin cell adhesion molecule 4, a type I transmembrane glycoprotein encoded by the NECTIN4 gene. Commonly referred to as Nectin-4 and also known as Poliovirus receptor related 4 (PVRL4), this protein is a member of the nectin family within the immunoglobulin superfamily. NECTIN4 localizes primarily to the plasma membrane at adherens junctions, where it mediates Ca2+-independent cell-cell adhesion and contributes to epithelial tissue integrity. Nectin cell adhesion molecule 4 antibody is widely used in studies of epithelial organization, cell polarity, and tumor-associated membrane protein expression.
NECTIN4 contains three extracellular immunoglobulin-like domains, a single transmembrane region, and a cytoplasmic tail that interacts with intracellular adaptor proteins involved in junction assembly and cytoskeletal linkage. Through homophilic and heterophilic interactions with other nectin family members, Nectin cell adhesion molecule 4 regulates adhesion strength, cell sorting, and tissue morphogenesis. In normal tissues, expression is relatively restricted, with detectable levels in skin, placenta, and select epithelial compartments. During development, nectin family proteins play roles in coordinated cell positioning and junctional maturation.
Overexpression of NECTIN4 has been reported in several epithelial malignancies, including urothelial carcinoma, breast cancer, lung cancer, and ovarian cancer. Elevated membrane expression has been associated with enhanced proliferation and tumor progression, supporting its relevance as a biomarker in oncology research. Immunostaining typically demonstrates membranous localization in positive tumor cells, consistent with its function as a cell surface adhesion molecule. Clone NECTIN4/9906 is designed to detect Nectin cell adhesion molecule 4 in research applications and supports investigation of epithelial adhesion dynamics, tumor biology, and membrane-associated signaling pathways. -
UniProt
- Q96NY8
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途径
- Cell-Cell Junction Organization
抗原
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