PEX14 抗体 (N-Term)
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Quick Overview for PEX14 抗体 (N-Term) (ABIN8093404)
抗原
See all PEX14 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- PEX14 Antibody / Peroxisomal biogenesis factor 14
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纯化方法
- Immunogen affinity purified
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Peroxisomal biogenesis factor 14 was used as the immunogen for the PEX14 antibody.
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亚型
- IgG
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anti-Peroxisomal Biogenesis Factor 14 (PEX14) (AA 118-377) antibody
PEX14 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peroxisomal Biogenesis Factor 14 (PEX14) (AA 1-377) antibodyPEX14 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Peroxisomal Biogenesis Factor 14 (PEX14) (AA 343-370), (C-Term) antibodyPEX14 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23197 unconjugated
anti-Peroxisomal Biogenesis Factor 14 (PEX14) (AA 121-150) antibodyPEX14 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB31100 unconjugated
anti-Peroxisomal Biogenesis Factor 14 (PEX14) (Internal Region) antibodyPEX14 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peroxisomal Biogenesis Factor 14 (PEX14) (AA 118-377) antibodyPEX14 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peroxisomal Biogenesis Factor 14 (PEX14) (AA 348-377), (C-Term) antibodyPEX14 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Peroxisomal Biogenesis Factor 14 (PEX14) (AA 288-507) antibodyPEX14 适用: Arabidopsis thaliana WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Peroxisomal Biogenesis Factor 14 (PEX14) (Internal Region) antibodyPEX14 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peroxisomal Biogenesis Factor 14 (PEX14) (AA 293-375) antibodyPEX14 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1G12 unconjugated
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应用备注
- Optimal dilution of the PEX14 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PEX14 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PEX14 (Peroxisomal Biogenesis Factor 14 (PEX14))
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别名
- PEX14
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背景
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PEX14 antibody targets Peroxisomal biogenesis factor 14, encoded by the PEX14 gene. Peroxisomal biogenesis factor 14 is an integral peroxisomal membrane protein that functions as a core docking component of the peroxisomal matrix protein import machinery. It serves as a binding site for cytosolic import receptors, including PEX5, enabling delivery of peroxisomal targeting signal-containing proteins to the peroxisome membrane.
Functionally, Peroxisomal biogenesis factor 14 acts as a central scaffold within the peroxisomal translocation complex. By interacting directly with PEX5-cargo complexes, PEX14 facilitates the initial stages of matrix protein import and coordinates assembly of the transient import pore. A PEX14 antibody supports studies focused on peroxisomal protein trafficking, membrane-associated import mechanisms, and organelle maintenance.
PEX14 is localized predominantly to the peroxisomal membrane, distinguishing it from mobile import receptors that shuttle between compartments. Its membrane-embedded position allows it to organize interactions between cytosolic receptors and other peroxins required for translocation. Through this role, Peroxisomal biogenesis factor 14 contributes to efficient import of enzymes essential for peroxisomal metabolic pathways, including lipid oxidation and redox regulation.
From a disease-related perspective, disruption of PEX14 function impairs peroxisomal matrix protein import and has been linked to peroxisome biogenesis disorders. Loss of functional PEX14 compromises peroxisomal enzyme content and organelle activity, leading to widespread metabolic consequences. These findings underscore the importance of PEX14 as a structural and functional hub in peroxisome assembly and maintenance.
At the molecular level, Peroxisomal biogenesis factor 14 contains conserved domains that mediate interactions with import receptors and other peroxisomal membrane proteins. Its apparent behavior in biochemical assays reflects its membrane-associated nature and interaction state rather than changes in protein size or sequence. PEX14 antibody reagents enable investigation of peroxisomal membrane organization and protein import pathways, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- O75381
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途径
- Maintenance of Protein Location
抗原
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