Recombinant PVALB 抗体 (full length)
Our Local Distributor
北京 101111
Quick Overview for Recombinant PVALB 抗体 (full length) (ABIN8093394)
抗原
See all PVALB 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
-
-
抗原表位
- full length
-
原理
- PVALB Antibody / Parvalbumin (azide and preservative free)
-
免疫原
- Recombinant full-length human PVALB protein was used as the immunogen for the Fast-Spiking Interneuron Marker/Parvalbumin antibody.
-
亚型
- IgG, kappa
-
-
anti-Parvalbumin (PVALB) (C-Term) antibody
Verified PVALB 适用: 人, 大鼠 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Parvalbumin (PVALB) (AA 2-110) antibodyPVALB 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Parvalbumin (PVALB) antibodyPVALB 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Parvalbumin (PVALB) (AA 1-110) antibodyPVALB 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Parvalbumin (PVALB) antibodyMicroarray verified PVALB 适用: 人 IHC 宿主: 小鼠 Monoclonal MAB572452 unconjugated
anti-Parvalbumin (PVALB) antibodyPVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 unconjugated
anti-Parvalbumin (PVALB) antibody (APC)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 APC
anti-Parvalbumin (PVALB) antibody (Atto 390)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 390
anti-Parvalbumin (PVALB) antibody (Atto 488)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 488
anti-Parvalbumin (PVALB) antibody (Atto 594)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 594
-
-
应用备注
- Optimal dilution of the Fast-Spiking Interneuron Marker/Parvalbumin antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
-
储存液
- Azide free
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Fast-Spiking Interneuron Marker/Parvalbumin antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
-
-
- PVALB (Parvalbumin (PVALB))
-
别名
- PVALB
-
背景
-
Fast-Spiking Interneuron Marker antibody, also known as Parvalbumin antibody, recognizes Parvalbumin, a small cytosolic EF-hand calcium-binding protein encoded by the human PVALB gene on chromosome 22q12.3. Commonly referred to as Parvalbumin or PV in the neuroscience literature, this protein is predominantly localized to the cytoplasm and is highly expressed in fast-spiking GABAergic interneurons of the cerebral cortex, hippocampus, and cerebellum. It is also present in fast-twitch skeletal muscle fibers. Fast-Spiking Interneuron Marker antibody is widely used to identify interneuron subpopulations that regulate cortical excitability and synchronize neuronal network activity.
Parvalbumin functions primarily as an intracellular calcium buffer. Structurally, it contains three EF-hand motifs, two of which are functional calcium-binding domains capable of binding calcium with high affinity. This buffering capacity allows rapid sequestration of calcium following action potentials, supporting high-frequency firing and precise synaptic timing in inhibitory interneurons. In skeletal muscle, Parvalbumin accelerates relaxation after contraction, particularly in glycolytic fast-twitch fibers. During postnatal brain development, Parvalbumin expression increases as inhibitory circuits mature and gamma oscillatory activity becomes established.
Within the central nervous system, Parvalbumin-positive interneurons often co-localize with synaptic proteins involved in vesicle release and cytoskeletal organization, reflecting their specialization for rapid neurotransmission. Disruption of Parvalbumin-expressing interneurons has been associated with neurological and psychiatric conditions including epilepsy, schizophrenia, and autism spectrum disorders, where altered inhibitory tone and impaired network synchronization are implicated. In muscle biology, Parvalbumin expression correlates with fiber type specification and metabolic properties.
Fast-Spiking Interneuron Marker antibody is suitable for detecting Parvalbumin expression in studies of neural circuitry, neurodevelopment, and muscle physiology. Recombinant monoclonal clone PVALB/12610R is produced using defined expression systems to promote lot-to-lot consistency and reliable performance. A Parvalbumin antibody such as clone PVALB/12610R supports research focused on inhibitory interneuron identification and calcium-buffering protein analysis. -
UniProt
- P20472
抗原
-
