Recombinant PVALB 抗体 (full length)
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Quick Overview for Recombinant PVALB 抗体 (full length) (ABIN8093392)
抗原
See all PVALB 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- full length
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原理
- PVALB Antibody / Parvalbumin (azide and preservative free)
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免疫原
- Recombinant full-length human PVALB protein was used as the immunogen for the Calcium-Binding Protein PV/PVALB antibody.
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亚型
- IgG, kappa
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anti-Parvalbumin (PVALB) (C-Term) antibody
Verified PVALB 适用: 人, 大鼠 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Parvalbumin (PVALB) (AA 2-110) antibodyPVALB 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Parvalbumin (PVALB) antibodyPVALB 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Parvalbumin (PVALB) (AA 1-110) antibodyPVALB 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Parvalbumin (PVALB) antibodyMicroarray verified PVALB 适用: 人 IHC 宿主: 小鼠 Monoclonal MAB572452 unconjugated
anti-Parvalbumin (PVALB) antibodyPVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 unconjugated
anti-Parvalbumin (PVALB) antibody (APC)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 APC
anti-Parvalbumin (PVALB) antibody (Atto 390)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 390
anti-Parvalbumin (PVALB) antibody (Atto 488)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 488
anti-Parvalbumin (PVALB) antibody (Atto 594)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 594
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应用备注
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1. Optimal dilution of the Calcium-Binding Protein PV/PVALB antibody should be determined by the researcher.
2. This Calcium-Binding Protein PV/PVALB antibody is recombinantly produced by expression in human HEK293 cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Calcium-Binding Protein PV/PVALB antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- PVALB (Parvalbumin (PVALB))
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别名
- PVALB
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背景
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Calcium-Binding Protein PV antibody, also known as PVALB antibody, recognizes Parvalbumin, a small cytosolic EF-hand calcium-binding protein encoded by the human PVALB gene on chromosome 22q12.3. Commonly referred to as Parvalbumin or PV in the literature, this protein is predominantly localized in the cytoplasm and is highly expressed in fast-twitch skeletal muscle fibers and in specific subsets of inhibitory GABAergic interneurons within the cerebral cortex, hippocampus, and cerebellum. Calcium-Binding Protein PV antibody is widely used to identify fast-spiking interneurons that play a central role in regulating cortical excitability and network synchronization.
Parvalbumin functions as a high-affinity intracellular calcium buffer. Structurally, it contains three EF-hand motifs, two of which are functional calcium-binding domains that rapidly bind calcium following membrane depolarization. This buffering activity accelerates muscle relaxation in fast-contracting fibers and shapes the timing and precision of inhibitory synaptic transmission in neurons. In the developing brain, Parvalbumin expression increases during postnatal maturation of interneurons, coinciding with the refinement of inhibitory circuitry and establishment of gamma oscillations.
In skeletal muscle biology, Parvalbumin levels correlate with glycolytic fast-twitch fiber identity and metabolic specialization. In the central nervous system, Parvalbumin-positive interneurons often co-localize with synaptic proteins involved in vesicle docking and release, reflecting their specialization for rapid, high-frequency firing. Altered expression or dysfunction of Parvalbumin-expressing interneurons has been associated with neurological and psychiatric disorders including epilepsy, schizophrenia, and autism spectrum disorders, where disrupted inhibitory signaling contributes to abnormal cortical dynamics.
Calcium-Binding Protein PV antibody is suitable for detecting Parvalbumin expression in studies of neural circuitry, muscle physiology, and disease-related alterations in calcium homeostasis. Recombinant monoclonal clone PVALB/12794R is produced using defined expression systems to promote consistent performance and supply reliability. A PVALB antibody such as clone PVALB/12794R supports research focused on calcium-buffering proteins and fast-spiking neuronal populations. -
UniProt
- P20472
抗原
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