Recombinant PVALB 抗体 (AA 1-110)
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Quick Overview for Recombinant PVALB 抗体 (AA 1-110) (ABIN8093390)
抗原
See all PVALB 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-110
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原理
- PVALB Antibody / Parvalbumin (azide and preservative free)
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免疫原
- A recombinant fragment (around amino acids 1-110) of human PVALB protein (exact sequence is proprietary) was used as the immunogen for the PV/Parvalbumin alpha antibody.
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亚型
- IgG1, kappa
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anti-Parvalbumin (PVALB) (C-Term) antibody
Verified PVALB 适用: 人, 大鼠 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Parvalbumin (PVALB) (AA 2-110) antibodyPVALB 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Parvalbumin (PVALB) antibodyPVALB 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Parvalbumin (PVALB) (AA 1-110) antibodyPVALB 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Parvalbumin (PVALB) antibodyMicroarray verified PVALB 适用: 人 IHC 宿主: 小鼠 Monoclonal MAB572452 unconjugated
anti-Parvalbumin (PVALB) antibodyPVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 unconjugated
anti-Parvalbumin (PVALB) antibody (APC)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 APC
anti-Parvalbumin (PVALB) antibody (Atto 390)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 390
anti-Parvalbumin (PVALB) antibody (Atto 488)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 488
anti-Parvalbumin (PVALB) antibody (Atto 594)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 594
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应用备注
- Optimal dilution of the PV/Parvalbumin alpha antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- PV/Parvalbumin alpha antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- PVALB (Parvalbumin (PVALB))
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别名
- PVALB
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背景
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PV antibody, also known as Parvalbumin alpha antibody, recognizes a small cytosolic EF-hand calcium-binding protein commonly referred to as Parvalbumin. Encoded by the human PVALB gene on chromosome 22q12.3, Parvalbumin alpha is predominantly localized to the cytoplasm and is highly expressed in fast-twitch skeletal muscle fibers and specific subsets of inhibitory GABAergic interneurons in the cerebral cortex, hippocampus, and cerebellum. PV antibody is widely used as a marker for fast-spiking interneurons that regulate network synchronization and inhibitory tone in the central nervous system.
Parvalbumin alpha functions primarily as an intracellular calcium buffer. It contains three EF-hand motifs, two of which are functional calcium-binding domains that bind calcium with high affinity. By rapidly sequestering calcium following depolarization, Parvalbumin accelerates muscle relaxation in fast-twitch fibers and shapes the timing and precision of synaptic transmission in inhibitory neurons. Expression of Parvalbumin increases during postnatal development as inhibitory circuits mature, making PV antibody valuable in studies of neurodevelopment and circuit refinement.
In skeletal muscle, Parvalbumin levels correlate with fiber type specification and metabolic specialization, with enrichment in glycolytic fast-contracting fibers. Within the brain, Parvalbumin-positive interneurons often co-localize with synaptic proteins involved in vesicle release and cytoskeletal organization, supporting their specialized role in high-frequency firing. Altered Parvalbumin expression or interneuron density has been associated with neurological and psychiatric conditions including epilepsy, schizophrenia, and autism spectrum disorders, where impaired inhibitory signaling contributes to cortical dysfunction.
Clone rPVALB/9839 is a recombinant monoclonal antibody generated by controlled expression systems to promote lot-to-lot consistency and long-term supply stability. A PV antibody such as clone rPVALB/9839 is suitable for detecting Parvalbumin alpha expression in studies of neural circuitry, muscle physiology, and disease-related alterations in calcium-buffering proteins. -
UniProt
- P20472
抗原
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