Recombinant PVALB 抗体
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北京 101111
Quick Overview for Recombinant PVALB 抗体 (ABIN8093387)
抗原
See all PVALB 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PVALB Antibody / Parvalbumin
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免疫原
- Prokaryotic recombinant fusion protein corresponding to the majority of the parvalbumin alpha molecule was used as the immunogen for the PVALB/Parvalbumin antibody.
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亚型
- IgG1, kappa
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anti-Parvalbumin (PVALB) (C-Term) antibody
Verified PVALB 适用: 人, 大鼠 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Parvalbumin (PVALB) (AA 2-110) antibodyPVALB 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Parvalbumin (PVALB) antibodyPVALB 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Parvalbumin (PVALB) (AA 1-110) antibodyPVALB 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Parvalbumin (PVALB) antibodyMicroarray verified PVALB 适用: 人 IHC 宿主: 小鼠 Monoclonal MAB572452 unconjugated
anti-Parvalbumin (PVALB) antibodyPVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 unconjugated
anti-Parvalbumin (PVALB) antibody (APC)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 APC
anti-Parvalbumin (PVALB) antibody (Atto 390)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 390
anti-Parvalbumin (PVALB) antibody (Atto 488)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 488
anti-Parvalbumin (PVALB) antibody (Atto 594)PVALB 适用: 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 小鼠 Monoclonal C12 Atto 594
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应用备注
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1. Optimal dilution of the PVALB/Parvalbumin antibody should be determined by the researcher.
2. This PVALB/Parvalbumin antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- PVALB/Parvalbumin antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- PVALB (Parvalbumin (PVALB))
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别名
- PVALB
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背景
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PVALB antibody, also known as Parvalbumin antibody, recognizes a small cytosolic EF-hand calcium-binding protein commonly referred to as Parvalbumin. Encoded by the human PVALB gene on chromosome 22q12.3, Parvalbumin is predominantly localized to the cytoplasm and is highly expressed in fast-twitch skeletal muscle fibers and in distinct populations of inhibitory GABAergic interneurons in the cerebral cortex, hippocampus, and cerebellum. Within the central nervous system, Parvalbumin-positive interneurons are widely studied for their role in fast-spiking activity and synchronization of neuronal networks.
Parvalbumin functions as an intracellular calcium buffer. It contains three EF-hand motifs, two of which are functional calcium-binding domains that bind calcium with high affinity. By rapidly sequestering calcium following depolarization, Parvalbumin accelerates muscle relaxation in fast-twitch fibers and shapes the timing and precision of synaptic transmission in inhibitory neurons. This buffering activity contributes to gamma oscillations and tight control of excitatory signaling. During postnatal brain development, Parvalbumin expression increases as inhibitory circuits mature, making it a useful marker of interneuron differentiation and circuit refinement.
In skeletal muscle, Parvalbumin levels correlate with fiber type specification and metabolic specialization. Its expression is enriched in glycolytic, fast-contracting fibers and is lower in slow-twitch oxidative fibers. In the kidney and other peripheral tissues, Parvalbumin expression is more restricted but detectable in specific epithelial populations. Dysregulation of Parvalbumin-positive interneurons has been associated with neurological and psychiatric disorders including epilepsy, schizophrenia, and autism spectrum disorders, where altered inhibitory tone and network synchronization are implicated.
PVALB antibody is commonly used to identify Parvalbumin-expressing interneurons in brain tissue and to characterize muscle fiber composition. Recombinant monoclonal clone r2E11 is generated by recombinant expression systems to ensure consistent antibody production and batch-to-batch reproducibility. A Parvalbumin antibody such as clone r2E11 is suitable for detecting Parvalbumin expression in neurobiological, developmental, and muscle physiology research applications. -
UniProt
- P20472
抗原
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