Recombinant MUC4 抗体 (AA 1729-1860)
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Quick Overview for Recombinant MUC4 抗体 (AA 1729-1860) (ABIN8093345)
抗原
See all MUC4 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1729-1860
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原理
- MUC4 Antibody / Mucin 4 (azide and preservative free)
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纯化方法
- Protein A affinity
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免疫原
- A recombinant fragment (around amino acids 1729-1860) of human MUC4 protein (exact sequence is proprietary) was used as the immunogen for the recombinant Sialomucin Complex Subunit 4 antibody.
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亚型
- IgG, kappa
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anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1730-1864) antibody
MUC4 适用: 人 IHC 宿主: 小鼠 Monoclonal MUC4-3084 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1730-1864) antibodyMUC4 适用: 人 IHC 宿主: 小鼠 Monoclonal MUC4-3105 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 79-188) antibodyMUC4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5B12 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) antibodyKD Validated MUC4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2595 unconjugated Recombinant Antibody
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1501-1613) antibodyMUC4 适用: 人 WB, IHC (p), IF (p), IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 529-560), (N-Term) antibodyMUC4 适用: 人 WB 宿主: 兔 Polyclonal RB49957 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 79-188) antibodyMUC4 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1250-1444) antibodyMUC4 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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1. Optimal dilution of the recombinant Sialomucin Complex Subunit 4 antibody should be determined by the researcher.
2. This recombinant Sialomucin Complex Subunit 4 antibody is recombinantly produced by expression in CHO cells. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Sialomucin Complex Subunit 4 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- MUC4 (Mucin 4, Cell Surface Associated (MUC4))
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别名
- MUC4
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背景
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Sialomucin Complex Subunit 4 antibody targets Mucin-4, a large transmembrane glycoprotein encoded by the human MUC4 gene and a member of the membrane-bound mucin family. Sialomucin complex subunit 4 refers to the membrane-associated component of the heterodimeric MUC4 complex that was originally characterized as part of the ascites sialoglycoprotein system. In the literature, Sialomucin Complex Subunit 4 antibody, MUC4 antibody, and Mucin-4 antibody are used to describe detection of the same epithelial mucin protein that plays critical roles in barrier function and tumor biology.
MUC4 is synthesized as a high molecular weight precursor that undergoes proteolytic processing into two subunits that remain non-covalently associated at the cell surface. These are historically described as ASGP-1 and ASGP-2, with Sialomucin complex subunit 4 corresponding to the membrane-spanning ASGP-2 component. The extracellular region contains heavily O-glycosylated tandem repeat domains that contribute to mucosal protection, while the membrane-associated subunit contains epidermal growth factor-like domains, a transmembrane region, and a cytoplasmic tail involved in intracellular signaling. Sialomucin Complex Subunit 4 antibody is therefore valuable for investigating epithelial differentiation and membrane-associated signaling pathways.
In normal tissues, Mucin-4 expression is largely restricted to glandular and ductal epithelial cells of the respiratory, gastrointestinal, and genitourinary tracts. During malignant transformation, MUC4 expression frequently becomes upregulated and loses apical polarity, contributing to altered cell adhesion, increased tumor cell survival, and enhanced metastatic potential. Elevated MUC4 expression has been documented in pancreatic, breast, lung, ovarian, gastric, and colorectal carcinomas.
Mucin-4 has been shown to interact with receptor tyrosine kinases such as ERBB2, modulating downstream pathways that regulate proliferation and resistance to apoptosis. A Sialomucin Complex Subunit 4 antibody such as clone MUC4/8660R is suitable for detecting MUC4 expression in epithelial tissues and tumor biology research applications. -
UniProt
- Q99102
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途径
- Regulation of Leukocyte Mediated Immunity
抗原
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