MUC4 抗体 (AA 1730-1864)
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Quick Overview for MUC4 抗体 (AA 1730-1864) (ABIN8093343)
抗原
See all MUC4 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1730-1864
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原理
- MUC4 Antibody / Mucin 4 (azide and preservative free)
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免疫原
- A recombinant fragment (around amino acids 1730-1864) of human MUC4 protein (exact sequence is proprietary) was used as the immunogen for the ASGP-2/MUC4 antibody.
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亚型
- IgG1, kappa
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anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1730-1864) antibody
MUC4 适用: 人 IHC 宿主: 小鼠 Monoclonal MUC4-3084 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1730-1864) antibodyMUC4 适用: 人 IHC 宿主: 小鼠 Monoclonal MUC4-3105 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 79-188) antibodyMUC4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5B12 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) antibodyKD Validated MUC4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2595 unconjugated Recombinant Antibody
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1501-1613) antibodyMUC4 适用: 人 WB, IHC (p), IF (p), IHC (fro), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 529-560), (N-Term) antibodyMUC4 适用: 人 WB 宿主: 兔 Polyclonal RB49957 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 79-188) antibodyMUC4 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1250-1444) antibodyMUC4 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the ASGP-2/MUC4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- ASGP-2/MUC4 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.
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- MUC4 (Mucin 4, Cell Surface Associated (MUC4))
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别名
- MUC4
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背景
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ASGP-2 antibody targets Mucin-4, a large transmembrane glycoprotein encoded by the human MUC4 gene and a member of the membrane-bound mucin family. ASGP-2, short for Ascites sialoglycoprotein 2, represents the membrane-associated subunit of the MUC4 heterodimer that was originally characterized in ascites tumor cells. In the literature, ASGP-2 antibody and MUC4 antibody are used interchangeably because ASGP-2 corresponds to the membrane-bound component of Mucin-4. This historical nomenclature remains relevant in cancer biology and epithelial differentiation studies.
MUC4 is synthesized as a high molecular weight precursor that undergoes proteolytic processing into two subunits, commonly referred to as ASGP-1 and ASGP-2, which remain non-covalently associated at the cell surface. The extracellular domain contains heavily O-glycosylated tandem repeat regions that contribute to mucosal barrier function. In normal tissues, Mucin-4 expression is primarily localized to glandular and ductal epithelial cells of the respiratory, gastrointestinal, and genitourinary tracts. During malignant transformation, MUC4 expression frequently becomes upregulated and loses apical polarity, contributing to altered cell adhesion, enhanced tumor cell survival, and increased metastatic potential. ASGP-2 antibody is therefore valuable for evaluating epithelial tumor progression and differentiation status.
Mucin-4 has been shown to interact with receptor tyrosine kinases such as ERBB2, modulating downstream signaling pathways involved in proliferation and resistance to apoptosis. Elevated MUC4 expression has been documented in pancreatic, breast, lung, ovarian, gastric, and colorectal carcinomas, where it may correlate with aggressive disease and poor clinical outcome. ASGP-2 antibody supports investigations into these oncogenic signaling mechanisms and tumor-associated expression patterns.
Structurally, the ASGP-2 subunit contains epidermal growth factor-like domains, a transmembrane region, and a cytoplasmic tail involved in signal transduction. An ASGP-2 antibody such as clone MUC4/2863 is suitable for detecting MUC4 expression in epithelial tissues and carcinoma research applications. -
UniProt
- Q99102
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途径
- Regulation of Leukocyte Mediated Immunity
抗原
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